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Healthy, smooth and silky hairs are something that everybody wishes to have. But due to improper hair care, e

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nvironmental pollution and stressful life it has really become a dream today. One should know the proper caus

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e of his or her hair loss to cure the hair loss problem from the root.

Hair Loss Causes

• Hormonal p

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

oblems are one of the main causes of hair loss. If your thyroid gland is under active or overactive, you will

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

suffer the problem of hair loss. This hair loss generally can be cured by treatment of the thyroid disorder.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Hair loss may occur if androgens (male hormones) or estrogens (female hormones) are out of balance. Clinical

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

treatment of hormone imbalance may stop your hair loss.

• Pregnant women also notice hair loss problems with

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

n a period of about 3 months after delivery. During pregnancy, high levels of particular hormones cause the b

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ody to keep hair that would normally fall out. When the hormones return to pre-pregnancy levels, that hair fa

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ls out and the normal growth and loss cycle starts again.

• Some fungal infections also cause hair loss. Gen

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

erally, children may have hair loss problems caused by a fungal infection of the scalp. This type of fungal i

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nfection can be easily treated with antifungal medicines.

• Certain medicines (mainly sulphur drugs) can cau

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e hair loss. This type of hair loss problem improves when you stop taking the medicine. Medicines that can ca

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

use hair loss include anticoagulants (also known as blood thinners), medicines utilized in chemotherapy to tr

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

at cancer, medicines used for gout, vitamin A (if too much is taken), birth control pills, and antidepressant

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s.

• If you have undergone a major operation or have suffered a prolong illness you can face the problem of

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

air loss. However, this hair loss is related to the stress of the illness and is temporary.

Disclaimer: This

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

article is not meant to provide health advice and is for general information only. Always seek the insights

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

Reserved. If you want to use this article on your website or in your ezine, make all the urls (links) active

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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