E-Articles - Health and Fitness

As we grow older changes take place in our hormones and with this comes a decrease in the number of active hair follicles t

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

hat a person has. However, although this is a change which will take place in us all as we grow older for some people they

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

will lose their hair earlier in life because of either a hormonal change, their genetics or a disease. Through this articl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

we hope to explain just what the causes of hair loss are.

The most common cause of hair loss is known as androgenetic alo

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

pecia. It can be found in both men and women and in the US between 7 and 15% of men by the age of 25 will experience it an

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

by the time they reach 35 almost 40% will suffer from it to some degree. This is natural age related problem and will rep

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

esent over 95% of all hair loss that is found in men. However, the exact cause for this form of hair loss in men is not kn

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

own but it is clear that the genetic makeup of a person plays a huge part in their having it. Unfortunately those people w

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

o have more of the hormone androgens in their body then the faster they will lose their hair. The easiest way of assessing

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

a man's chances of whether they will develop male pattern hair loss is by looking at their male relatives. They should sta

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t by looking at their own father's and grandfather's and then at their mother's father as well. If your mother's father su

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ffers from it then you at a high risk of suffering from male pattern hair loss as well. Certainly the male pattern hair lo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s gene can easily come from a man's mother as well as the father, but it may not be as noticeable in the mother as it often

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

is much slower to develop in women than in men.

Next we will take a look at telogen effluvium. This is often caused throu

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

gh stress it may be a death in the family, pregnancy, illness, a crash weight loss program or that you are worrying about s

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

mething serious happening that can affect the hair follicles. It is believed that stress causes a major change to a large

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ortion of the hair follicles and moves them from the growing stage to the rest stage. When hair follicles go into the rest

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

stage they then let go of the hair that is already in place but does not actually provide new hair to replace that which i

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

lost. This is the second most common cause for hair loss after androgenetic alopecia.

Above we have shown the two main c

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

uses of hair loss that women and men can suffer from and there are others which we will discuss later on in another article

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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