E-Articles - Health and Fitness

At any one point in time, about 10 percent of the hair on your scalp is in a resting phase. After 2 to 3 months, the resting hair b

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

egins to fall out and new hair begins to regenerate in its place. This growing phase lasts for 2 to 6 years. Each hair grows approx

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

mately 1 centimeter per month during this phase. About 90 percent of the hair on your scalp is growing at any one time. It is norma

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

to shed some hair each day as part of this cycle. However, some people may experience excessive (more than normal) hair loss – and

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

this is not discriminatory – it affects men, women and children alike.

There are plenty of reasons for hair loss. For instance, h

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

rmonal problems may cause hair loss. If your thyroid gland is overactive or underactive, your hair may fall out. This hair loss usu

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

lly can be helped by treatment of the thyroid disease. Hair loss may occur if male or female hormones, known as androgens and estro

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ens, are out of balance. Correcting the hormone imbalance may stop your hair loss.

Many women also notice sometime significant hai

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

loss about 3 months after they've had a baby. This loss is also related to hormones. During pregnancy, high levels of certain horm

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

nes cause the body to keep hair that would normally fall out. When the hormones return to pre-pregnancy levels, that hair falls out

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

and the normal cycle of growth and loss starts again. This is just the body readjusting itself to life after pregnancy.

Some medic

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nes can cause hair loss. This type of hair loss improves when you stop taking the medicine. Medicines that can cause hair loss incl

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

de blood thinners (also called anticoagulants), medicines used for gout, medicines used in chemotherapy to treat cancer, vitamin A

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

if too much is taken), birth control pills and antidepressants.

Certain infections can cause hair loss. Fungal infections of the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

calp can cause hair loss in children. The infection is easily treated with antifungal medicines. Finally, hair loss may occur as pa

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t of an underlying disease, such as lupus or diabetes. Since hair loss may be an early sign of a disease, it is important to find t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e cause so that it can be treated.

Yes. If you wear pigtails or cornrows or use tight hair rollers, the pull on your hair can caus

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

a type of hair loss called traction alopecia (say: "al-oh-pee-sha"). If the pulling is stopped before scarring of the scalp develo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s, your hair will grow back normally. However, scarring can cause permanent hair loss. Hot oil hair treatments or chemicals used in

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

permanents (also called "perms") may cause inflammation (swelling) of the hair follicle, which can result in scarring and hair loss

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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According to a recent report, foreclosures appear to be increasing in the South: 2006 Mid-year Market Analysis listed five southern states in its top ten highest foreclosure rates to date.

Are you a person who buckles when you want to express your displeasure about some demand made of you? Do you just take it on whether you want to or not? Do you then feel angry, frustrated, trapped and helpless to change the course of events? Well this article may save you your life.

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