E-Articles - Health and Fitness

With all the talk these days about Propecia I figured that this little pill needed a closer look. It is the only FDA approved drug for the treatment of male pattern baldness and it i

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s being touted by many as the only thing that actually does something to stop the nightmare of a receding hairline. Many men have been quick to accept these claims and they take this

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

pill every day but do they really know what they are taking?

First of all, the name of the actual ingredient in Propecia that should get all the credit for fighting the battle at th

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

front lines of the war on receding hairlines is called finasteride. Some chemists working for the drug company Pfizer invented it in a laboratory and it does some pretty amazing thi

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

gs. It is a 4-azasteroid compound that is a specific inhibitor of the Type II 5 alpha-reductase. In plain English, it basically prevents androgen testosterone from being converted in

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

o 5-dihydrotestosterone, or DHT. This preventative process stops your hair follicles from dying, which allows more hair to grow on your head.

The enemy, known as DHT is an enzyme th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

t is found primarily in the prostate, seminal vesicles, epididymides, hair follicles and liver. These particular parts of the body account for approximately 67 percent of the DHT tha

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

circulates in the bodies of men. The war on baldness is going on at an intracellular level and finasteride is your army that is fighting gallantly for you against an evil enzyme.

H

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

re are some particulars of the actual ingredient finasteride. It is a white crystalline powder with a melting point of 250 degrees Celsius. If you put finasteride in lower alcohol so

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

vents it will freely dissolve, but it is almost insoluble when placed in water. Most Propecia pills available contain 5 mg of finasteride. They are film-coated tablets that also cont

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

in the inactive ingredients hydrous lactose, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, hydroxypropylmethyl cellulose LF, hydroxypropylmethyl cellulo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e, titanium dioxide, magnesium stearate, talc, docusate sodium, FD&C Blue 2 aluminum lake and yellow iron oxide. These inactive ingredients are mostly just the bonding and filling a

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ents that it takes to make a little pill of Propecia that men can take every day.

There are some warnings when it comes to who can and cannot take Propecia. Women should not take it

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nor should anyone who has liver problems. This is due to the fact that this drug works on the enzyme DHT which is primarily produced in the liver.

In most studies that have been pe

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

formed on men between the ages of 18-54 who used Propecia on a daily basis for several months 65 percent showed an increase in hair growth over areas of the front and top of the scal

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

. Once the active ingredient finasteride interacts with the hair follicles in bald areas of the scalp, the follicles seem to come back to life. Hair begins to grow again, and so does

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

your self esteem. So it would seem that Propecia is the best product available for men to use in the treatment of male pattern baldness, otherwise known as alopecia. The side effects

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

are minimal and the process is as easy as taking a pill. The results have been very positive in the hair growth department.

In the war against a receding hairline it is good to know

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

that a little white crystalline powder know as finasteride is fighting the battle for you at the intracellular level against a very destructive force known as 5-dihydrotestosterone,

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

r DHT. In plain English, if you cannot afford a hair transplant and you want to know what the next best choice would be to have a better head of hair, Propecia seems to be the answer

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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