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    Hypertension, or high blood pressure, is one of the leading causes of morbidity and mortality now a days. Blood pressure can play havoc on blood vessels and internal organs, if left untreated, setting the stage for the development of a heart attack, stroke, or kidney failure.

    In people with mild to moderate blood pressure, lifestyle changes; combined with helpful natural nutritional supplements, can dramatically lower blood pressure and may eliminate the need for prescription drugs as well.

    Th
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    ere are so many Ayurvedic herbs and modern food supplements for prevention and treatment of hypertension. These can be used as an adjuvant to the drug therapy.

    Vitamin C in the form of Amla Juice ( Amla Saar)

    Vitamin C is one of the most important antioxidant that is required by the body for removal of free radicals. The free radicals are the substances that are formed during various metabolic processes within our body. They are also formed because of stress, pollution, smoking, synthe
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    ic drugs etc.They damage the inner lining of our arteries and are responsible for ageing, wrinkles, premature death. Stress and anxiety increase the formation of free radicals many times. Vitamin C is a very important anti-oxidant which scavenges free radicals and protects us from their harmful effects.

    The antioxidant vitamin C may also help lower high blood pressure and cholesterol and helps in formation of arterioneogenesis. i.e. formation of new arteries. Recent studies found that higher bl
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    ood levels of vitamin C were correlated with lower systolic and diastolic blood pressure.

    Amla is the richest natural source of Vitamin C. It has 30 times more vitamin C than oranges. Pure Amla juice Can be consumed dailiy for prevention of complications of hypertension as well as many other dreadful diseases.

    Coenzyme Q10

    Co-Enzyme Q 10 is the natural vitamin like micronutrient which is required by the heart muscle for proper functioning. It provides energy to the heart muscle cell
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    . The daily requirement for prevention of heart disease and cholesterol maintenance is between 30 to 60 mg/day.

    Natural Co-Enzyme Q 10 is present in the bark of a tree “Terminalia arjuna”. Ayurveda recommends Terminalia arjuna to be taken in the form of “Arjuna Ksheer pak” i.e. in a herbal tea form. This tea of Arjun should be boiled in milk and water because the Co-Enzyme Q 10 is better absorbed with milk lipids. Co-Enzyme Q 10 also helps in normalizing blood cholesterol levels.

    Suggested
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    ose: While making Arjun tea one should use 3 to 5 gm of the herb powder and boil it in milk and water to get maximum benefits.

    Flaxseed and Fish Oils

    Flaxseed is the only vegetarian source of Omega-3 fatty acids, very essential to keep the cholesterol levels in control. Flaxseed oil should be consumed by people suffering from disturbed cholesterol metabolism. Flaxseed oil is used in Ayurveda for prevention of heart problems, cancers and many other chronic ailments. It has been shown
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    to reduce high blood pressure in numerous double-blind studies. Only extra virgin cold pressed Flaxseed Oil should be used for oral consumption. It should not be heated or used for cooking. The Omega-3 fatty acids get destroyed if the oil is heated or used for cooking. It should be refrigerated to ensure freshness and efficacy. For cooking purpose, Mustard oil or Olive oil can be used.

    Suggested dose : Flaxseed oil: 1 tbsp. (14 grams) a day. Take with food to enhance absorption.

    Fi
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    h oils: 1,000 mg 3 times a day. Use fish oil supplements if you don't eat fish at least twice a week. Keep refrigerated to ensure freshness

    Garlic

    Garlic is another wonderful natural remedy to keep cholesterol and heart related problems away. It inhibits clot formation by making platelets less likely to clump, and it can help lower cholesterol levels and prevent formation of artery-clogging plaques. Garlic contains compounds which are good for digestion of lipids and heavy diets. Ac
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    ording to Ayurveda Garlic is extremely useful for “Vata” and "Kapha" conditions and is a miracle cure for paralysis and motor nerve disorders. Garlic should be avoided in cases of high blood pressure as it may increase "Pitta". So it is recommended only in cases of high cholesterol without blood pressure.

    Suggested dose: 500 mg twice a day i.e. 1-2 buds once daily. It can be taken with honey or boiled in milk to reduce the heating effect.

    Ashwgandha ( Withania somnifera)

    Ashwga
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    ndha is also known as “Indian Ginseng” in international herbal market. This herb has marvelous properties to alleviate stress, anxiety. It is known to possess adaptogenic properties i.e. it helps body to adapt to various stresses and cope with them. It is rejuvenates cells, relieves fatigue and gives strength to the neuromuscular system. In Ayurveda it is used in rheumatic conditions and as a sexual stamina enhancer. It also increases the low sperm counts and is very useful in infertility. Reg
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    lar use of Ashwagandha with milk is recommened in emaciation of children, protein energy malnutrition as well as insomnia in elderly due to stress and hypertension. Stress related blood pressure responds very well to Ashwagandha.

    Suggested Dose : Ashwagandha root powder can be taken 3-6 gm twice daily with lukewarm water or milk.

    Brahmi ( Indian Peenywort)

    This slender, creeping plant grows commonly in localized swampy areas of Asia, Africa, and the tropics. The size of an old B
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    itish colonial-period penny — this is how it came to be known as Indian pennywort, marsh penny and water pennywort (with "wort" being the ancient anglo-saxon word for plant). . It is famous in western world as ‘Gotu Kola’. Gotu Kola Enhances Tranquility and regulates sleep pattern. It is a wonderful herb not only for blood pressure but also for memory weakness, lack on concentration It is regarded as one of the most spiritual and rejuvenating herbs in Ayurveda. Today, this herb has become popula
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    r to promote relaxation, cleanse the blood, enhance brain function, and for strengthening the collagen fibers of the body's connective tissues and circulatory vessels.

    Since so often we find high blood pressure is related to daily stress, Gotu kola is an important herb for blood pressure patients. Boiled in water or direct juice can be taken at night for sound sleep and restlessness. It effectively controls blood pressure without causing any side effects.

    Suggested Dose:

    Brahmi juice
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    an be taken 20 to 30 ml twice daily with equal quantity of water. Brahmi powder can be taken 3-6 gm per day with lukewarm water.

    Aloe Vera Juice (Kumari Saar)

    Aloe vera is also called “ The miracle plant”. It has been studied to be effective in so many illenesses. The plant has outer thick leaf and inner soft gel. Aloe gel contains active substances known as glycoproteins and polysaccharides. Glycoproteins are protein-carbohydrate compounds that speed the healing process by stopping p
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    in and inflammation. Polysaccharides are a type of carbohydrate that stimulates skin growth and repair. They also help control the blood sugar levels and thus very useful in treating diabetes. These substances are also thought to stimulate the immune system. Aloe vera juice lowers down cholesterol levels by acting on liver metabolism. It increases the working capacity of liver cells. In Ayurveda it is known as “Kumari”. Kumari is said to possess the properties of removing endotoxins from the bod
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    y. It is explained as

    “Kumari bhedni sheeta tikta netrya rasayani Madhura brahni balya vrishya vaat vish pranut” Classical Ayurvedic Text. BPN- verse- 230. ( 1700 A.D)

    i.e. Aloe vera removes endotoxins, it is soothing, bitter tonic, improves eyesight, rejuvenative (Anti-ageing), strengthens body, enhances immunity, increases vigour and vitality, relieves ‘Vata’ and removes ‘poisons’ from the body. Cholesterol is considered as endotoxin or “Aama” according to Ayurveda. The best prop
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    rties of “ Kumari Saar” the inner juicy portion of Aloe vera is to remove this ‘Aama’ from our body. According to Ayurveda this ‘Aama’ is the reason for formation of uric acid crystals, Gall bladder stones, Rheumatoid arthritis, Cysts and fibroids, cholesterol deposits. So Aloe vera juice is a very useful herb in a number of diseases including blood pressure and cholesterol.

    Suggested dose: Aloe vera juice can be taken 20 ml twice daily diluted with equal water.

    Shankhpushpi ( Convolvulus p
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    uricaulis)

    Shankhpushpi is another useful herb famous for improving memory in children. The herb has cold, bitter tonic, relieves pitta and heat inside the body. It is also useful for high metabolic rates, wear and tear reactions. It calms down the hyperactive neurons and thus controls the blood pressure and improves memory. It also heals stomach and duodenal ulcers. This herb gives wonderful results in stress and anxiety related hypertension.

    Suggested dose: 20 ml of Shankhpushpi
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    juice or syrup can be taken twice daily for one month to get good results.Shankhpushpi powder (Buy Total Heart Support containing Ashwagandha, Brahmi, Arjuna and many other herbs for heart problems) can be consumed 1 teaspoonful twice daily with luke warm water.

    Haritaki ( Terminalia chebula)

    Terminalia chebula is also commonly known as ‘Harar’ an age old remedy to relieve constipation. In Ayurveda, Haritaki is considered as mother of all herbs. Ayurveda considers ‘Vayu’ as a major cul
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    rit for hypertension. ‘Haritaki’ in combination with another two herbs ‘Amla’ and ‘Bahera’ makes the famous Ayurvedic preparation ‘Triphala’. Triphala is best combination to get rid of hypertension, constipation and high cholesterol. Haritaki alone is very useful for lowering down blood cholesterol levels as well as controlling bouts of hypertension.

    Suggested dose:

    Haritaki powder or Triphala powder/ Triphala capsules can be taken 3-6 gm(1 tablespoon) once at night with lukewarm water


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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