E-Articles - Health and Fitness

High blood pressure or hypertension is a condition that sneaks up on people slowly, so slowly that many people have it, and don't even know it. In fa

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ct, one in every three Americans develops the condition. Most people think only older people suffer with hypertension, but the disease strikes many

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ounger people every day.

High blood pressure is no longer something that you get when you are fifty and working a high-profile job. Teenagers get it

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

and even younger children. Today, the prevalence of high fat, high sugar diets do not help, and the rising rate of obesity is one of the major reaso

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s more people suffer with the condition today. While the disease may last a lifetime, it is possible to treat and control it, sometimes with a mere

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

hange in diet and exercise, though for others, treatment comes in the form of medication.

Everyone has a blood pressure, as it is vital to life. The

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

heart pumps blood through its chambers, and from there throughout the body's arterial system. That oxygen rich blood is distributed throughout body

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rgans, tissues and cells and then, once deoxygenated, returns through the veins back to the heart for a fresh dose of oxygen. The heart of a normal pe

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

son beats around 80 to120 times each minute. Those who are in excellent physical health and teenagers may have lower pressures. Anything within about

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

10 to 120 is great. You normally measure blood pressure in two parts. The first number in a blood pressure reading is the pressure exerted by the hear

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

when it performs the pumping action. The second number is measures the heart at rest, between beats. So, a normal blood pressure reading could be 120

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

/80, for example.

Medical experts consider someone who is at risk of high blood pressure "prehypertensive", if the blood pressure reading is within

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

20-139 beats each minute, systolic pressure, which again, comes from the first measurement. Similarly, the bottom pressure, the diastolic measurement

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

may be anywhere between 80 to 90.

There are two different stages of high blood pressure. Stage One occurs when the blood pressure reading of any g

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ven individual is between 140-158 for a systolic reading. The bottom pressure measurement, the diastolic reading, can range from around 90-98. These

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

umbers are not definite. You need to consider other things when getting a blood pressure reading. Is the person overweight, on medications or just f

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nished exercising? While these figures may sound alarming, proper diet and exercise, combined with medications, may be enough to get blood pressure b

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ck under control.

Stage Two high blood pressure occurs when the systolic pressure ranges over 160, while the bottom pressure reads over 100. It is

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

good idea to get blood pressure checked at least once a year, and if it is borderline, talk to your doctor about treatment choices. Don't mess aroun

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

with your heart. It is the only one you will have in your lifetime, unless you need a transplant. You and your doctor can treat high blood pressure

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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This article gives various guidelines on how to choose the right airline credit card.

Many think inf is nothing more than a set of data or output specifications; others see it as nothing more than a programming spec. Rarely, does anyone want to take the time to truly understand information requirements and prefer, instead, to get down to the business of programming where they feel more comfortable.

Do you break out in a sweat when you are in a public place? Do you hate going to a crowded restaurant? You are not alone ...

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