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Those who suffer from Anemia either have a reduced number of red blood cells or a reduced amount of hemoglobin (the component of red blood cells that attaches to oxygen and transports it in the blood). Since there is less oxygen available to the cells in the body,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

Anemics have less energy to perform normal functions. The most common cause of Anemia is iron deficiency... iron is used to make hemoglobin. Most Anemics are on medication for life. We are interested in fixing the nutritional deficiencies underlying the condition

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

to heal the ailment completely.

Iron is a trace mineral of vital importance to the body. Although there is only about a teaspoon of it in your body at any one time, it is essential in the formation of Hemoglobin, the red pigment of blood. There are two types of i

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

on: Heme and Non-Heme. Now, Heme is more easily absorbed by the gastro-intestinal tract (10-30%) while Non-Heme is only about1-10% absorbed. Heme is available in the tissues of animals. That's right, the more available source of iron is found in meats and dairy th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

n in plants. But we suggest only obtaining your iron from vegetable sources. Why?

The interesting fact is that despite a less absorbable form of iron, vegetarians are no more likely to suffer from iron deficiency than non-vegetarians. Draper and Wheeler have stat

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ed there is no indication of increased prevalence of iron deficiency amongst vegetarians. Anderson found the iron status of long-term vegetarian women to be adequate, despite a high intake of fiber and phytate which INHIBITS the absorption of iron!

In fact, becau

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e iron can be stored in the body, too much iron can cause problems. Too much iron consumption leads to the production of free radicals (a molecule with an extra electron that will steal a negatively charged hydrogen electron from DNA, tissues, or organs which caus

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s disease and aging). High levels of iron have also been found in association with heart disease and cancer. The buildup of iron in the tissues has been associated with a rare disease known as hemochromatosis, a hereditary disorder of iron metabolism that causes b

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

onze skin pigmentation, cirrhosis of the liver, diabetes, and heart disorders. All of this leads us to the conclusion that despite animal foods, you should never get your iron from a supplement. First, the pill will not have all of the other organic nutrients (cop

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

per, manganese, molybdenum, Vitamin A, and the B complex) necessary to absorb the iron safely. Second, in pills, you will get something like ferrous oxide (oxidized iron: In other words, RUST).

Symptoms:

Weakness, fatigue, ove

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

all pallor, dizziness, pale lips and eyelids, depression, pale and brittle nails, and coldness of the extremities

Recommendations:

An all natural whole food supplement can be helpful. ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

m/vitaforce_p_215-81.html" target="_blank">VITAFORCE™ is extremely abundant in organic iron and has extraordinary blood building properties. Iron is up to 16 times more absorbable if taken with Vitamin C and this is properly balanced naturally in VITA

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ORCE™. It is also extremely rich in all the other nutrients necessary for healthy blood.

If you are anemic, then drink juices rich in chlorophyll. Chlorophyll is responsible for the green pigment in plants (called the "blood" of plants). Chlorophyll has a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

lmost the exact same chemical makeup of hemoglobin (less one iron molecule), both are responsible for carrying oxygen in the blood. Since the chemical makeup is almost identical, chlorophyll can quickly and easily be converted to hemoglobin. If the juices are rich

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

in organic iron, then you have all the qualities for a blood transfusion. For example, the fresh organic juice of carrots, beets and beet greens dramatically increases the red blood cell count in the body. Dark leafy vegetables and especially They have extraordina

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

y blood-building properties.

Other foods that contain iron are asparagus, bananas, beets, dulse, kelp, whole grains (esp. millet & kamut), leafy greens, raisins, parsley, peas, plums, squash, prunes, purple grapes, broccoli, and yams.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ings to Avoid:

All inorganic supplemental forms of iron; none of the iron supplements use organic iron, so you cannot absorb any of it and it gets pissed away or lodged in your tissues where it can cause disease.
Caffeine and tannins (in

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

tea), and calcium inhibit iron absorption. So, avoid coffee and tea.

Beer, candy bars, dairy products (milk, cheese, butter, ice cream, etc...), and soft drinks. Additives in these foods interfere with the absorption of iron.

Foods containing ox

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

lic acids inhibit the absorption of iron. Eat only in moderate amounts; almonds, cashews, chocolate, cocoa, soda, and most nuts and beans. References:

1) James F. Balch, M.D, Phyllis A. Balch, C.N.C, "Prescription for Nutritional Heal

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ng," (1997)

2) Anderson, B. et al. The iron and zinc status of long-term vegetarian women. Am J of Clin Nutr v.34 (6),(1981):p.1042-1048.3) Draper, A. & Wheeler, E. The diet and food choice of vegetarians in Greater London. Center of Human Nutrition, London.(1989

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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