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E-Articles - Fantastic Fibers
“It’s the healthiest gift you can give your body,” was my grandmother’s
breakfast message about the oatmeal she served me 50 years ago.
She would be amused to know that the last 10 years of medical science have given proof to her intuition about the value of whole oats. Grandma would also chuckle that I am still following her breakfast advice with added ingredients like fresh or frozen berries.
Oatmeal and berries have a health value i
She would be amused to know that the last 10 years of medical science have given proof to her intuition about the value of whole oats. Grandma would also chuckle that I am still following her breakfast advice with added ingredients like fresh or frozen berries.
Oatmeal and berries have a health value i
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
n common; they are not only nutritious
in multiple ways but are also related as great fiber sources with important
health benefits now recognized by the US Food and Drug Administration, Health
Canada and European Medicines Evaluation Authority.
The FDA lists whole oats, barley and psyllium seed husk as excellent sources of dietary fiber that can reduce cancer risk via regular dietary intake.
Health Benefits of Fiber in the Diet
Consum
The FDA lists whole oats, barley and psyllium seed husk as excellent sources of dietary fiber that can reduce cancer risk via regular dietary intake.
Health Benefits of Fiber in the Diet
Consum
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
ed as long as people have eaten plants, dietary fiber has recently come
into the view of governments, nutrition advisory groups and the public as one of
our most important dietary macronutrients.
However, nutritionists have estimated that Canadians and Americans consume less than 50% of the required daily fiber amount to maintain intestinal health and its multiple other benefits.
Consistent intake of fiber through foods like whole grai
However, nutritionists have estimated that Canadians and Americans consume less than 50% of the required daily fiber amount to maintain intestinal health and its multiple other benefits.
Consistent intake of fiber through foods like whole grai
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
ns, berries and other
fresh fruit, vegetables, seeds and nuts is now associated with reduced risk of
some of the world’s most prevalent diseases including:
· Several types of cancer
· Obesity
· Type 2 diabetes
· High blood cholesterol
· Cardiovascular disease
· Numerous gastrointestinal disorders (constipation, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, diverticu
· Several types of cancer
· Obesity
· Type 2 diabetes
· High blood cholesterol
· Cardiovascular disease
· Numerous gastrointestinal disorders (constipation, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, diverticu
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
itis and colon cancer)
Fiber Health Benefits
Recent medical research has proven several physiological benefits of consuming fiber, among which are:
Improved absorption of calcium, magnesium, and iron
Reduction of blood cholesterol and triglyceride levels
Stabilization of blood glucose levels after a meal, i.e., a low glycemic index
food source
Maintenance of an optimal intestinal environment
Stimulation of immune responses
Over the pa
Fiber Health Benefits
Recent medical research has proven several physiological benefits of consuming fiber, among which are:
Improved absorption of calcium, magnesium, and iron
Reduction of blood cholesterol and triglyceride levels
Stabilization of blood glucose levels after a meal, i.e., a low glycemic index
food source
Maintenance of an optimal intestinal environment
Stimulation of immune responses
Over the pa
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
st 30 years, government agencies around the world have undertaken
analyses and definitions of fiber to more accurately describe this dietary
nutrient. Among some 32 reports filed, the most universally accepted definition
is one by the American Association of Cereal Chemists. The AACC focused on the
physiological and metabolic significance of fiber, defining it as:
“…[T]he edible parts of plants or similar carbohydrates resistant to dige
“…[T]he edible parts of plants or similar carbohydrates resistant to dige
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
stion
and absorption in the human small intestine with complete or partial
fermentation in the large intestine.”
Recognizing these facts, advisories now exist in several countries for increasing adult intake of dietary fiber to 30 grams per day, double the current intake levels. Achieving this goal has been difficult because high-fiber foods do not always taste good and may lack other qualities needed to attract consumers.
Resista
Recognizing these facts, advisories now exist in several countries for increasing adult intake of dietary fiber to 30 grams per day, double the current intake levels. Achieving this goal has been difficult because high-fiber foods do not always taste good and may lack other qualities needed to attract consumers.
Resista
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
t Starch and Fermentation Provide Health Benefits
Let’s review some properties of how our bodies use fiber. “Resistant starch” (same as “resistant carbohydrates”) is a term sometimes used to refer to fiber sources resistant to complete digestion in the small intestine. These fiber sources need to pass through to the large intestine perhaps only attracting water along the way. In the large intestine they undergo fermentation by the co
Let’s review some properties of how our bodies use fiber. “Resistant starch” (same as “resistant carbohydrates”) is a term sometimes used to refer to fiber sources resistant to complete digestion in the small intestine. These fiber sources need to pass through to the large intestine perhaps only attracting water along the way. In the large intestine they undergo fermentation by the co
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
lonic bacteria.
We should remember that fermentation of fiber is normal and healthy, even if fiber products sometimes cause minor gastric discomfort when the user has not previously had sufficient fiber in their diet.
“Fermentation” is one normal biological process many people never consider when they eat healthy foods like fresh berries or vegetables. Fermentation simply is the breakdown of soluble, resistant starch comprised mainly o
We should remember that fermentation of fiber is normal and healthy, even if fiber products sometimes cause minor gastric discomfort when the user has not previously had sufficient fiber in their diet.
“Fermentation” is one normal biological process many people never consider when they eat healthy foods like fresh berries or vegetables. Fermentation simply is the breakdown of soluble, resistant starch comprised mainly o
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
f carbohydrate
molecules in the large intestine, yielding gases and further useful chemicals
like short-chain fatty acids. A typical property of soluble fibers is to bind
water forming a viscous gel having numerous health benefits during passage
through the digestive system.
Other dietary fiber sources include polysaccharides (starch or sugar chains of dozens to many hundreds or thousands of units), oligosaccharides (short-chain sug
Other dietary fiber sources include polysaccharides (starch or sugar chains of dozens to many hundreds or thousands of units), oligosaccharides (short-chain sug
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
rs, usually 2-20 units long), monosaccharides, lignins and “insoluble” fiber
sources such as cellulose, plant waxes and collagens. Insoluble fiber sources,
however, do not undergo fermentation, but are nevertheless valuable for their
water-attracting properties that aid bowel regularity.
Some of the soluble fiber sources you may see in public news and a variety of functional foods are:
o Pectins, a seed-like component common in be
Some of the soluble fiber sources you may see in public news and a variety of functional foods are:
o Pectins, a seed-like component common in be
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
rries, fruits, legumes
o Cellulose from brans and many vegetables
o Beta-glucans in whole oats and barley
o Plant waxes from many edible species
o Polyfructoses from inulin and oligofructans
o Gums and mucillages from tree exudates, fermentation of corn syrup (xanthan gum), algae (agar, carageenan) and grain seeds (e.g., psyllium seed husk)
Should fiber be new to your diet, add sources of fi
o Cellulose from brans and many vegetables
o Beta-glucans in whole oats and barley
o Plant waxes from many edible species
o Polyfructoses from inulin and oligofructans
o Gums and mucillages from tree exudates, fermentation of corn syrup (xanthan gum), algae (agar, carageenan) and grain seeds (e.g., psyllium seed husk)
Should fiber be new to your diet, add sources of fi
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
ber to your diet gradually
over a month. This will allow your intestinal system to adjust slowly until the
30 grams per day of fiber become your normal intake. Drink plenty of water. If
you have persistent discomfort from using fiber sources, speak with your doctor
or a nutritionist.
Fiber Fermentation and Prebiotic Nutrient Value
The process of intestinal fermentation involves action by natural bacteria, sometimes called flora, resi
Fiber Fermentation and Prebiotic Nutrient Value
The process of intestinal fermentation involves action by natural bacteria, sometimes called flora, resi
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
ding in our large intestine (primarily the colon).
These bacteria require soluble fiber as fuel and as sources for fermentation to
produce valuable chemicals and health benefits.
Since the fiber serves as food for the bacteria already in the intestine, this is called a “prebiotic” nutrient value, meaning that before the bacteria can serve their main purpose in digestion—producing enzymes that digest food—they must be fed with a substr
Since the fiber serves as food for the bacteria already in the intestine, this is called a “prebiotic” nutrient value, meaning that before the bacteria can serve their main purpose in digestion—producing enzymes that digest food—they must be fed with a substr
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
te they prefer (i.e. fermentable fibers). The main
intestinal flora are bifidobacteria and lactobacilli that are essential for our
health.
Berry pectins, inulin, psyllium and xanthan gum, all mentioned in the above list, are sources of soluble fibers that provide this prebiotic function in the normal fermentation process.
The Rubus berries such as the blackberry (Rubus nigra) and red raspberry (Rubus idaeus) have the highest density
Berry pectins, inulin, psyllium and xanthan gum, all mentioned in the above list, are sources of soluble fibers that provide this prebiotic function in the normal fermentation process.
The Rubus berries such as the blackberry (Rubus nigra) and red raspberry (Rubus idaeus) have the highest density
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
of dietary fiber per gram than any other
published food source.
Fermentation is a metabolic process involving the use of one organic source to create others, such as enzymes to digest food that then release new elements. Among products of fermentation are gases (methane, carbon dioxide, hydrogen, nitrogen) and short-chain fatty acids, which result as new molecules clipped from the more complex digested fiber and food compounds.
Short
Fermentation is a metabolic process involving the use of one organic source to create others, such as enzymes to digest food that then release new elements. Among products of fermentation are gases (methane, carbon dioxide, hydrogen, nitrogen) and short-chain fatty acids, which result as new molecules clipped from the more complex digested fiber and food compounds.
Short
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
-chain fatty acids such as butyric acid, acetic acid, propionic acid and
valeric acid make up about 90% of the total fatty acid yield from fermentation
in the human body. Collectively, these fatty acids have several beneficial
physiological effects in the large intestine worth repeating from above.
Fatty acids…
Enhance absorption of calcium, magnesium and iron (thus are important to bone and blood health)
Contribute to lowering blood
Fatty acids…
Enhance absorption of calcium, magnesium and iron (thus are important to bone and blood health)
Contribute to lowering blood
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
holesterol and triglyceride levels
Promote colon health by raising acidity levels that improve nutrient absorption and lower risk of colon cancer
Act as anti-inflammatory mediators
Stimulate immune protection through an array of intermediate effects within the intestinal system, including cytokine production
Appear to inhibit appetite, leading to reduced calorie intake and weight gain.
Insoluble fiber sources from plants, such as cellul
Promote colon health by raising acidity levels that improve nutrient absorption and lower risk of colon cancer
Act as anti-inflammatory mediators
Stimulate immune protection through an array of intermediate effects within the intestinal system, including cytokine production
Appear to inhibit appetite, leading to reduced calorie intake and weight gain.
Insoluble fiber sources from plants, such as cellul
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ose, typically undergo no
fermentation so do not contribute new elements. Rather, they bind water
effectively, making them valuable in digestion as stool softening agents with
the essential benefit of promoting bowel regularity.
Summary
Including more fiber in your diet is a crucial step towards a healthier lifestyle. From oatmeal to berries the combination of ways to creatively include this nutrient are countless. Why wait?
Readi
Summary
Including more fiber in your diet is a crucial step towards a healthier lifestyle. From oatmeal to berries the combination of ways to creatively include this nutrient are countless. Why wait?
Readi
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
ng
Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 40:235-43, 2006.
Kendall CW, Emam A, Augustin LS, Jenkins DJ. Resistant starches and health. J AOAC Int. 87:769-774, 2004.
Tungland BC, Meyer D. Nondigestible oligo- and polysaccharides (dietary fiber): their physiology and role in human health and food., Compreh Rev Food Sci Food Safety 1:73-92, 2002
Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 40:235-43, 2006.
Kendall CW, Emam A, Augustin LS, Jenkins DJ. Resistant starches and health. J AOAC Int. 87:769-774, 2004.
Tungland BC, Meyer D. Nondigestible oligo- and polysaccharides (dietary fiber): their physiology and role in human health and food., Compreh Rev Food Sci Food Safety 1:73-92, 2002
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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