E-Articles - Health and Fitness

Obesity in children and adolescents is a serious issue with many health and social consequences that often continue into adulthood. Obesity is the nominal form

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

of obese which comes from the Latin obesus, which means "stout, fat, or plump." Esus is the past participle of edere (to eat), with ob added to it. Several huma

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

cultures, plumpness was associated with physical attractiveness, strength, and fertility. Some of the earliest known cultural artifacts, known as Venus figurin

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s, are pocket-sized statuettes representing an obese female figure. Although their cultural significance is unrecorded, their widespread use throughout pre-hist

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ric. This is most likely due to their ability to easily bear children and survive famine. Obesity, especially central obesity (male-type or waist-predominant ob

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

esity), is an important risk factor for the "metabolic syndrome" ("syndrome X"), the clustering of a number of diseases and risk factors that heavily predispose

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

for cardiovascular disease.

Obesity has reached epidemic proportions in the United States. Obesity can run in families. Many families eat the same foods, have

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

he same habits (like snacking in front of the TV), and tend to think alike when it comes to weight issues (like urging children to eat a lot at dinner so they c

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

n grow "big and strong"). All of these situations can contribute to weight gain, so it can be difficult to figure out if a person is born with a tendency to be

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

obese or overweight or learns eating and exercise habits that lead to weight gain. Hypertension is common among obese adults. A Norwegian study showed that weig

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t gain tended to increase blood pressure in women more significantly than in men. In most cases, weight problems arise from a combination of habits and genetic

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

actors. Certain illnesses, like thyroid gland problems or unusual genetic disorders, are uncommon causes for people gaining weight.

Obesity is not just a cosme

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ic consideration; it is a dire health dilemma directly harmful to one's health. In the United States, roughly 300,000 deaths per year are directly related to ob

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

esity, and more than 80% of these deaths are in patients with a BMI (body mass index, which will be discussed later in this article) over 30. Obesity also incre

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ses the risk of developing a number of chronic diseases. In the United States, women are slightly more at risk for becoming obese than men. Race and ethnicity a

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

so can be factors - in adolescents, obesity is more common among African Americans. It is also associated with breathing problems such as asthma and sleep apnea

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

and problems with hips and knee joints that may require surgery.

Causes of Obesity

1.Genetics (hormones).

2.Overeating.

3.High diet of carbohydrates.

4.Slo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

w metabolism.

5.Psychological factors(stress and sadness).

Symptoms of Obesity

1.Large body frame.

2. Difficulty in doing daily activities.

3.Lethargy.

4

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Breathlessness.

5.Increased weight.

Treatment of Obesity

1.Lifestyle changes

2.Medications (Phentermine ,Sibutramine )

3.Surgery--Gastrointestinal surgery

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

.

4.Alternative and complementary therapies -5-HTP (5-Hydroxytryptophan); Acupuncture and Ayurveda.

5.Other treatments-Consider counseling or behavior therapy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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E-Articles - Obesity - Causes, Symptoms and Treatment

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