E-Articles - Health and Fitness

In this article I will discuss the primary factor that causes obesity. How the cycle of obesity starts, and what you can do to regain control of your health. In order to understand o

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

besity and what is probably the most important factor effecting obesity, you have to understand the mechanics of how the body functions when you put fuel into it .

You eat, Let’s say,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

chicken sandwich on wheat bread with mayonaisse and a 20 oz. soft drink . The protein from the chicken is broken down into amino acids, the fat from the mayonaisse into fatty acids and

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the carbohydrates from the bread into simple sugars (glucose). So far so good, as long as you are not consuming more calories than your body needs you will not gain weight, but here co

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

es the soft drink. A 20 oz. drink with 45 grams of sugar. Your blood sugar level spikes rapidly, this causes your pancreac to respond by releasing an equal spike of insulin. Insulin fo

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ces glucose into the cells at an alarming rate, this in turn causes the release of Free radicals from the cells. The Free Radicals cause the capillaries of your muscle tissue to become

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

inflamed. Your muscle tissue utilizes 80-90% of the calories that you consume but because the tissue is inflamed by the spike in blood sugar, your muscle has just lost most of its’ abil

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ty to process those calories.

Insulin also blocks fat from being released. Fat is nothing more than a “ Reserve Energy Storage Facility” This energy reserve will only be released if it

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

is needed. As long as there is plenty of available energy in the form of incoming calories, that fat is going to stay right where it is. Insulin is only released when food energy is be

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ng processed, when the body senses the release of Insulin it knows that the fat reserves are not needed and blocks the release of energy from those fat stores. Now that the tracks on yo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

r glucose train have been switched from your muscle cells to your fat cells, these calories are now Uber-calories. They are going right to your Storage Facility.

The calories are now s

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tored as fat because your muscle tissue has lost it’s ability to utilize them. After a short period of time, perhaps 30 minutes, your blood sugar level and Insulin level come crashing d

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

wn as your body tries to balance things out. You are left with a feeling of not only being tired, but a feeling of being hungry again. This is that “carb craving”, you just have to eat

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

something, usually another high glucose meal and the cycle starts all over again .

Most of what we think of as “emotional eating” is really just this vicious cycle.Normally when you wa

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

t to lose weight you go on a diet, you restrict the amount of calories you take in, but the problem is that this cycle is never really broken. So you fight these cravings while trying t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

eat less food, it becomes a contest of Biology against Phsycology .The game then becomes, how long can you stand the torment before you eventually give up. It takes 5 days of low glyc

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

emic meals to break this cycle. The first three days require some real determination to get through the withdrawal symptoms, by the fourth day youre’ feeling much better and on the fift

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

day the cravings are gone, you feel great, and you can learn to eat properly without the daily torment. There are certainly other factors that effect obesity that I will discuss in fu

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ture articles. It is my sincere hope that this article has shed some light for you on this problem of obesity. You can beat this, you can be free to eat normally, you can change your wh

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

le life , just never give up until you get where you want to be. It really is worth it. YOU are worth it.

Before beginning any diet or weight loss program always consult your physician

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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The GD0 record for medical billing of electronic claims has some strange field descriptions. This installment, covering fields 11 through 17, touches on some of those descriptions. Fear not, detailed explanations are included.

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Adolescence is a trying time for our teenagers. Flower remedies can provide emotionally stability through natural healing.

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