E-Articles - Health and Fitness

We are all guilty to some extent of eating for reasons other than because we are hungry. We eat because we are stressed, angry, annoyed, stressed again, partying, and just to fit in.

Probably

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the worst culprit is stress. Most of us suffer from relatively high levels of chronic stress from work, kids, partner, or the universe in general. Through evolution our bodies have been conditi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

oned to respond to stress: they trigger the familiar fight or flight response. This response releases chemicals which lead to fat storage.

With stress, the body produces more cortisol. Your ap

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

petite increases, and most likely your craving for high calorie sweets and fats. More calorie intake leads to more fat storage, which in turn could lead to insulin resistance. The body can in t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

he short term relieve stress from high fat/sugary foods. Unfortunately, for chronic stress, these high fat/sugary foods will lead to weight gain. Obesity leads to higher insulin resistance, and

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Type 2 diabetes. Insulin resistance increases the likelihood of heart disease, diabetes and some cancers.

Keeping your stress levels down should help to keep your weight down as well. Here are

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

a few tips to reduce your stress levels.

Adequate sleep.
During sleep your body produces the feel good hormones - serotonin and dopamine. These feel good factors help to r

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

educe your stress. See what happens when a baby is stressed - it cries itself to sleep. Another thing is if your body is not getting enough serotonin, it craves for sugary foods which also prov

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ide a quick, but short lived burst of serotonin.

Exercise.
High activity aerobic exercise which leaves you breathless also produces levels of serotonin. This is not to say

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

that active people have no stress - just that its normally kept at more manageable levels. Remember that all exercise is good in that you increase your calorie usage. So if you can't do aerobi

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

exercise just walk around - even just standing is better than sitting. Recently, I watched a programme on the TV channel Five which suggested that you could even lose weight chewing gum.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Outdoors.
Daylight causes the body to produce some feel good factors as well. Ever noticed that if you spend days scooped up in rooms with artificial light you begin to feel th

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e blues? As much as you can enjoy the outdoor scenery, while passively reducing your stress levels. Stay out of too much sun though - cancer is definitely something to avoid. Incidentally, ther

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e are artificial lights which are said to provide the full spectrum (or nearly) of the natural daylight. If so, they should be able to boost your feel good hormones as well. If you are always s

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

cooped up inside, you might to find out more about them. Personally, I have yet to try them.

Touch and be touched.
We all know that babies love being touched and cuddled

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

Seek out positive interactions with other people. Evidence suggests that this produces the social bonding hormone oxytocin, decreases blood pressure and lowers the effects of stress. This lead

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

s you being able to control your appetite better.Research also suggests that women benefit from a simple hug (they produce more oxytocin) - it helps to lower their stress levels. So if you are

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

a woman, get loads of hugs from people you care about. If you are a man, don't begrudge the lady a hug.

Sex.
Sex has a number of benefits, one of which is you get a phys

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ical workout. Research has also shown that sex, more so with a long term-partner, produces endorphins, oxytocin, and other feel-good hormones.

Music. Music

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

does wonders at relieving stress. There is no music type that equally effective for everyone. Just sit down and listen to the music of your choice, the music you are comfortable with.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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