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E-Articles - Obesity - Promising New Approaches to Weight Loss
The reasons why we gain weight are complex, and involve more than just dieting and exercise. Some people seem to eat till they drop yet stay slim, while others gain weight much more easily. Experts are finding that genetic factors play a bi
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
g part in weight gain.
This makes developing effective slimming technologies a bit more difficult. To be highly effective and long lasting, any weight loss technique must attack the root cause of obesity. This means a technique which worke
This makes developing effective slimming technologies a bit more difficult. To be highly effective and long lasting, any weight loss technique must attack the root cause of obesity. This means a technique which worke
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
d wonders for me, might not work for you.
However, there are a few interesting developments in the slimming world, as companies continue to pour millions of pounds into researching slimming approaches.
Excalia.
This drug
However, there are a few interesting developments in the slimming world, as companies continue to pour millions of pounds into researching slimming approaches.
Excalia.
This drug
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
works by fooling the body's metabolism into staying active, leading to an average weight loss of 12% a year. For many slimmers, there is usually an initial weight loss followed by a gain. One reason for this is that the body slows its meta
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
olism, which means you are using less calories, and have to worker hard to keep the weight off. Excalia tricks the hypothalamus into keeping the metabolism running fast, and also boosts a hormone that stops us getting hungry. This pill is s
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
aid to work faster and better than existing drugs.
Gut hormone - Oxyntomodulin.
This is a naturally occurring hormone. This hormone tells us we are full after a meal, but the obese have less of it. The idea is to trick th
Gut hormone - Oxyntomodulin.
This is a naturally occurring hormone. This hormone tells us we are full after a meal, but the obese have less of it. The idea is to trick th
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
e gut into sending the "I am full" signal to the brain, so you can stop eating sooner.
In studies, participants taking oxyntomodulin had a reduced appetite, but they saw no change in their enjoyment of food. On average they lost 2.3kg (5 p
In studies, participants taking oxyntomodulin had a reduced appetite, but they saw no change in their enjoyment of food. On average they lost 2.3kg (5 p
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
unds) in four weeks, compared to 0.5kg (1 pounds) for those on a dummy treatment. This drug could be available on the market within 4 years.
Free Electron Laser: Fat-zapping laser.
According to Dr Anderson at Harvard Medi
Free Electron Laser: Fat-zapping laser.
According to Dr Anderson at Harvard Medi
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
cal School, some people will always have pads of fat (on thighs etc) regardless of how much they exercise or eat. Its all in the genetics. Genetics governs where and how we store fat.
Currently, excess fat can be removed by liposunction. T
Currently, excess fat can be removed by liposunction. T
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
his is invasive and can lead to infections of the wound. A promising approach is to use laser to destroy all or some of the fat without breaking the skin. Scientists using the Free-Electron Laser were able to demonstrate the selective heati
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
g-up of fat, without damaging the overlying skin. Once heated the fat can then be broken up, and excreted by the body.
This laser technique has only been tested on animals, but with promising results. More needs to be done to see if it wor
This laser technique has only been tested on animals, but with promising results. More needs to be done to see if it wor
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
ks as well on humans and how long the effects will last, and of course if they are any long term side-effects.
Incidentally, the Free Electron Laser could also be used to treat acne.
Electrical treatment.
Another approac
Incidentally, the Free Electron Laser could also be used to treat acne.
Electrical treatment.
Another approac
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
h is to use electricity to trick the stomach into thinking you are full. Neural messages carried by the vagus nerve play a significant role in the regulation of ingestion, digestion and satiety.
The idea is to use a neuroregulator which de
The idea is to use a neuroregulator which de
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
livers very high frequency, low energy electrical pulses that completely block neural transmission along the vagal nerve. The VBLOC(Vagal blocking for Obesity Control) is inserted into the stomach, and blocks the vagal nerve which connects
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
he brain and the stomach.
The device prevents the stomach from increasing in size when you eat, and stops it emptying too quickly. Result? You fill full faster and for longer. This device is still in development at the Mayo Clinic. Expecta
The device prevents the stomach from increasing in size when you eat, and stops it emptying too quickly. Result? You fill full faster and for longer. This device is still in development at the Mayo Clinic. Expecta
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
tions are that you will achieve weight loss of at least 10-15%, similar to what you get from weight-loss drugs.
Incision-less surgery.
Currently, one of the most effective options for major weight reduction is surgery to
Incision-less surgery.
Currently, one of the most effective options for major weight reduction is surgery to
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
make the stomach smaller. The drawback of surgery is, because it's a wound, there are always risks. Incision-less surgery promises a way of reducing the stomach size without any incisions.
With NOTES ( Natural Orifice Trans Endoscopic Surg
With NOTES ( Natural Orifice Trans Endoscopic Surg
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
ry), an endoscope could be inserted through the mouth and down to the stomach. There it staples or stitches the stomach to make it smaller. Using this technique, it's possible for someone to leave hospital the same day. The whole procedure
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
could be done without anaesthetic.
Read More
Read More
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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