E-Articles - Health and Fitness

You probably already know why you are overweight. The causes of overweight or obesity naturally differ from individual to individual. Basi

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

cally, you will gain weight if your calorie intake (food eaten) is higher than the calories you use through exercise or normal activity.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Its all governed by this basic equation:

calories in - calories out = weight gain

The important thing to remember is its n

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

t the absolute quantity of food you eat that's important for weight control. Its the difference between what you eat and what you use.

He

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

re are some possible causes of overweight and obesity. No doubt, if you put your mind to it, you can greatly expand the list!

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

, an obvious candidate.

Physical activity or exercise. More like the lack of it!

Inheritance. Genes or bad eating habi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ts from parents.

Medical reasons. This is a rare cause of overweight.

In my view, the usual suspects when you gain we

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ght are overeating and exercise.

Overeating

I believe this is the number 1 reason why people gain weight. This is not a

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

bout stuffing yourself till your tummy is near bursting (that obviously makes it worse). We tend to overeat in more subtle ways. For insta

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ce if you tend to choose foods high in fat or calories-dense foods, you are more likely to gain weight. Better to choose foods such as who

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

le wheat bread, potatoes, or vegetables.

Have you been bored, upset,or just tired? Of course, who hasn't! Do you find yourself heading fo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

r the cupboards or fridge? That's using food as a 'quick-pick-me-up'. I am afraid that's bad news - more calories in.

We all love going t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

the pub for a pint with our friends. Nothing wrong with that, just remember that a pint of bitter is about 190 calories. That glass of wh

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ite wine generously gives you 113 calories. By all means go to the pub, but ease on the numbers.

Physical activity

In g

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

neral today's lifestyle is more sedentary than in the years gone past. The work is lighter, what with all those machines helping. Cars and

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

lifts mean we don't have to walk much anymore.

You can join a gym, of course. But then you might have a tight time budget, especially if

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

you have kids and you have to do house work. The first thing that gets squeezed out of the budget is the exercise regime ("after all I can

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

always do it tomorrow!"). Of course you may not be able to join a gym because its neither affordable nor practical.

In the home it doesn

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t get any better. We are spoilt for choice on what device to use so that we do less work. We have the remote control so that we don't we h

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ave to get up and go to the telly. On average, we watch more than 20 hours of TV(I know, this is in spite of not having time for exercise)

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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