E-Articles - Health and Fitness

Being overweight reaches beyond personal appearance and pride. If you are overweight, you are likely to trigger or worsen any number of healt

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

h problems. Obesity is now thought to be as big a cause of ill-health as smoking!

I have listed the major health problems associated with be

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ng obese or overweight. Its important to remember that I am not saying you will have these problems. Rather, your chances of having at least

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ne significantly increase the more excess weight you carry.

Heart disease and stroke

Heart disease and stroke ar

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the leading causes of death and disability in the western world. Being overweight increases your chances of angina and sudden death from hea

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

t disease and stroke. Recent research suggests that if your waist size is above 35 inches your risk of heart disease is high.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ng>High blood pressure

High blood pressure rarely makes you feel ill. That is not to say its harmless. It can lead to heart disease

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Being overweight is one of the causes of high blood pressure.

Diabetes

Noninsulin-dependent diabetes (Type 2 dia

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

etes) is the most common type of diabetes. About 8 in 10 people diagnosed with Type 2 diabetes are overweight. Carrying extra weight may caus

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

the insulin the body produces to work less effectively. This makes diabetes more likely to develop. The effect is more severe if the excess

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

eight is around the waist. One of the most serious long term risks of diabetes is cardiovascular disease.

Cancer

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Cancers of the colon, breast (postmenopausal), endometrium (the lining of the uterus), cervix, gall bladder, and ovary are associated with ob

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

sity in women. Overweight men are at greater risk of developing prostate cancer, cancer of the colon, and cancer of the rectum.

In 2002, it

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

as estimated that approximately 3% of all new cancers are linked with obesity. A recent study estimated that, in the United States, 14 percen

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

of deaths from cancer in men and 20 percent of deaths in women were due to overweight.

Snoring and sleep apnea

S

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

eep apnea causes a person to stop breathing for short periods during sleep. It can also cause daytime sleepiness. The more overweight you are

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

, the greater the risk of developing sleep apnea.

Osteoarthritis

This joint disorder normally affects joints in y

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ur knees, hips, and lower back. The extra weight increases the risk of osteoarthritis. The excess weight is thought to wear away the protecti

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e cartilage from the joints.

You also increase the risk of the following if you are overweight:

Stress, anxiety, and depr

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ssion

Gout

Vaginal prolapse of the rectum, womb, and/or bladder.

Poor recovery from medical operations

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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From those taking baby steps on the digital superhighway to those who've toured the block a few times - all need to heed a few universal rules to make sure their messages get noticed rather than become fodder for the recycle bin.

The goal of this command is love, which comes from a pure heart and a good conscience and a sincere faith. Some have wandered away from these and turned to meaningless talk. They want to be teachers of the law, but they do not know what they are talking about or what they so confidently affirm.

Nutritional therapy offers an alternative approach to help relieve the symptoms and severity of chronic health disorders.

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