E-Articles - Health and Fitness

Obesity is a problem that is growing at an alarming rate affecting many people and it is also a factor that leads to other serious conditions such as heart disease or diabetes. Treatments can inc

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

lude prescription weight loss medication, over the counter supplements, or both.

Weight loss medication when combined with regular exercise and a reduced calorie diet can help with weight loss.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ifferent medications affect the body differently. Some reduce the appetite making a person feel full, while others speed up the metabolism and burn fat, or even all three combined.

Prescription

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

eight loss medication should be used only by those that have an increased risk of another medical condition because of a weight problem and they should be used only under the direction of a physic

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

an. They should not be used for cosmetic weight loss such as losing 10 pounds. Prescription weight loss medicine has been approved for use on individuals with a BMI that is above 30 or for those

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

that have a BMI of 27 combined with obesity related conditions. Side effects from prescription weight loss medications are generally mild however as with any medication there is the potential for

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

serious side effects. You will need to discuss all of your options with your doctor.

For those that are not in need of medical intervention for weight loss but are looking for a cosmetic change

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

n their weight, there are many over the counter products which will do the job. Choose wisely as some are more hype than effective. As with prescription medications many reduce the appetite whil

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

increasing metabolism and burns fat.

Some products contain ephedrine, ephedra, and caffeine and the safety of these drugs is still unknown. There have been reports that link these compounds to

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

troke, heart attack, and seizure that can result in death. Some countries have banned the use of ephedrine and ephedra. When using ephedrine or caffeine based products always make sure that you

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

re over 18, do not have any heart problems such as high blood pressure and that you are not pregnant or lactating. It is important to always use caution when starting a new weight loss supplement

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nd remember that even though it is over the counter it is still potent.

With so many products out in the market place, there are many which do not help with weight loss. So here are just a few th

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t appear to be showing promising results.

• Conjugated Linoleic Acid or CLA has been involved in several studies and has been found to reduce body fat, increase lean muscle tissue and reduce the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

isk of cancer.

• Derived from a fruit, Hydroxycitric Acid or HCA inhibits an enzyme that converts carbohydrates to fat and it also suppresses the appetite. There have been mixed results in studi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s. It is recommended that a diet lower in fiber will give better results.

• Derived from the white kidney bean Phaseolamine works by reducing the amount of starchy carbohydrates that the body ab

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

orbs which means you absorb fewer calories to help with weight loss. Studies have shown as much as 10% body fat loss in 30 days.

• 5HTP (5-Hydroxy-tryptophan) increases serotonin levels in the b

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ain which result in weight loss, improved sleep and better mood. Studies have shown it is an excellent appetite suppressant and results in excellent weight loss over a 6 week period. Most users w

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

re happy while they lost their weight thanks to its mood enhancing abilities.

• L-carnitine is an amino acid which has been shown to encourage the body to burn stored fats for fuel/energy instead

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

of carbohydrates. Very effective when taken before exercise.

The quest for the perfect body will never end and thus a multi billion dollar industry will continue to flourish. Healthy weight loss

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

can be achieved by including exercise and good nutrition with the right weight loss medication or supplement. It’s important for a person to find the best combination for their personal situation

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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