E-Articles - Health and Fitness

While obesity is bad for health but the wrong way to diet can also be harmful to your health. Common examples are

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

anorexia, bulimia, and binge eating disorders. These are illnesses where extreme emotions, attitudes, and behavi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ors surround weight and food issues. These are serious emotional and physical problems with life-threatening cons

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

equences. Anorexia Nervosa is an illness by self-starvation and excessive weight loss.

Symptoms of the illness

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

nclude:

Refusal to maintain body weight at or above the minimal normal weight for height, body type, age, and ac

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tivity level
Intense fear of gaining weight or being “fat” or "obese".
Feeling “fat” or overweight desp

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ite being at a below normal body weight
Overwhelming obsession with body weight and shape

Bulimia Nervo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

a is a condition of marked over-eating followed by purging through vomiting or diarrhea using laxatives, all done

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

in secrecy. These patients stuff themselves on large amounts of food - within a short period of time, and then g

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

et rid of the food and calories through vomiting, laxative abuse, or over-exercising.

Symptoms of this illness i

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

clude:

Repeated episodes of bingeing and purging
Feeling out of control during a binge and eating beyond th

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e point of being "full"
Purging after a binge (typically by self-induced vomiting, abuse of laxatives, diet

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

pills and/or diuretics, excessive exercise, or fasting)
Frequent dieting
Overwhelming obsession with bo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

dy weight and shape

Compulsive Overeating is characterized primarily by periods of uncontrolled, impulsive,

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r continuous eating beyond the point of feeling "full". While there is no purging, there may be fasting or repeti

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

tive dieting and often feelings ashame of one self following a binge. People who overeat compulsively usually str

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

uggle with anxiety, depression and loneliness, which can contribute to their unhealthy episodes of binge eating.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hese patients can be normal in their weight, slightly overweight or obese.

Peer pressure that values "thinness"

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

and obtaining the "perfect body" can be a social force for some patients to enter this pattern of self-destructio

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

n. Learn to beat Obesity the right way. Through exercise and the right diet, I believe that obesity can be beaten

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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With current market conditions tossing most portfolios around, it would make sense to protect your portfolio. After all, the work we do significantly lowers the risk of losing money in an investment we choose to get involved in. But we never completely eliminate all the risk in the market.

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