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E-Articles - Risk Factors That Can Lead To Obesity
Obesity is itself a risk factor for many diseases and can lead to complications like high blood pressure, diabetes, heart attacks, stroke, gallstones etc.
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
But there are many factors, which can increase your risk of weight gain & obesity. You can not change or modify some of the risk factors like genetics, bu
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
there are some risk factors that you can change. Risk factors for obesity are:
High calorie diet:
Consumption of too many calories or high ca
High calorie diet:
Consumption of too many calories or high ca
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
lorie foods and not getting enough physical activity to burn those calories results in weight gain & obesity.
1 gm of carbohydrate provides 4 calories, 1
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
m of protein - 4 calories and 1 gm of fat - 9 calories. So, foods with high fat content are rich in calories. Also, foods & beverages like soft drink, dess
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
rts, which are high in sugar can also lead to weight gain.
Physical inactivity:
Your body weight is mainly determined by the balance between
Physical inactivity:
Your body weight is mainly determined by the balance between
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
your calorie intakes from food with the calories you burn in daily activities. Inactivity or sedentary lifestyle is a major risk factor for obesity because
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
extra calories, which are not used in physical activities, are deposited in body as fat.
Psychological & emotional factors:
Psychological fac
Psychological & emotional factors:
Psychological fac
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
ors can change eating habits. Some people overeat to deal with emotions like stress, boredom, anger & sadness.
Genetics factors:
Sometimes, o
Genetics factors:
Sometimes, o
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
besity runs in families & if your parents are obese, your chances of being overweight are also high.
Age:
Incidence of obesity increases with
Age:
Incidence of obesity increases with
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
increase in age. As physical activity level decreases with age, if caloric intake is not adjusted then extra calories will be deposited as fat.
Cigaret
Cigaret
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
e smoking:
Nicotine from cigarette increases metabolic rate of your body. High metabolic rate means more burning of calories by the body. When yo
Nicotine from cigarette increases metabolic rate of your body. High metabolic rate means more burning of calories by the body. When yo
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
u quit smoking, you may gain weight temporarily.
However, cigarette smoking is associated with lot of health problems and benefits of stopping cigarettes
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
exceed the risk of temporary gain in weight. You can avoid this weight gain by increasing physical activity & reducing calorie intake.
Drugs:
Drugs:
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
Certain medications like corticosteroids, tricyclic antidepressants, antipsychotic medications can increase your risk of being obese.
Diseases or medic
Diseases or medic
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
al conditions:
Obesity is associated with certain medical conditions like hypothyroidism (low thyroid function), Cushing’s syndrome (excess hormo
Obesity is associated with certain medical conditions like hypothyroidism (low thyroid function), Cushing’s syndrome (excess hormo
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
e production by adrenal gland), arthritis (due to decrease physical activity).
Alcohol:
Alcohol contains calories & it also increases appetit
Alcohol:
Alcohol contains calories & it also increases appetit
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
. So, drinking alcohol can lead to weight gain due to the caloric content of the alcohol as well as its appetite-enhancing effects.
So, you can control yo
So, you can control yo
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ur weight by changing modifiable risk factors like high calorie diet, physical inactivity, and sedentary lifestyle & avoid complications of obesity.You can
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
get details on complications of obesity at complications of obesity
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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