E-Articles - Health and Fitness

WHO reported that there are already 1 billion adults who are overweight and 300, 000 of them are considered obese. The rising number of overwe

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ight and obese people has grown at an alarming rate; it has even reached worldwide epidemic proportions. Causes of obesity have been linked to

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

over consumption of food that are high in sugar and saturated fats that are animal-based, sedentary lifestyle, and the changing eating pattern

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s among cultures in highly urbanized cities around the world. Obesity is one of the many causes of hypertension, type 2 diabetes, cardiovascul

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

r diseases and certain type of cancer.

Today obesity has become one of the most public health concerns especially among developing countries.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

If this issue is not addressed to immediately, people will be at risk of fatal diseases because of obesity. Medical science the world over ha

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

continuously in search of medical breakthroughs on obesity. This is in response to the worldwide demand to alleviate health-related risk of

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

obesity.

A study in Albert Einstein College of Medicine’s medical researchers has yet to be proven as one of the medical breakthroughs on obe

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ity. According to the research that maintaining the level of fatty acids in the brain may be the cure to obesity. Moreover the study aims to a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lter the effects of molecular substance malonyl CoA. This molecule is believed to have been an influence on the activity of the hypothalamus,

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

hich in effect increases the appetite of a person. If the scientist can found a way to modify the content of malonyl CoA in the brain, people

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

will no longer crave for so much food. This study is posing promise to treat obesity to children and adults alike, though it is yet to be test

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

d on humans.

Medical scientists from Imperial College have found a way to suppress the craving for food among humans. Injecting a drug that i

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ncreases the oxyntomodulin level in the stomach was being conducted among diabetic patients. This hormone, which is produced naturally by the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ody sends message to the brain that the stomach is full. The mechanism works as though the person is feeling full already. The other benefit o

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

f the drug is that it has no side effects since the body produces it naturally. The obese patients themselves can administer it.

Medical brea

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

throughs on obesity have gone as far as gene modification on human subjects. The issue on medical research ethics may impede the impetus of pr

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

oviding answers to obesity concerns. However, medical breakthroughs on obesity continue to surface as more and more scientists found a way to

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nswer weight problems and health risks caused by obesity.

The key to a disease-free life is self-discipline and healthy active lifestyle. Tru

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ly, an ounce of prevention is still better than a pound of cure. If one always bears this in mind, obesity will be out of someone’s vocabulary

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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