E-Articles - Health and Fitness

According to screaming headlines everywhere, Britain (and, more noticeably, the U.S.) is in the grip of an obesity epidemic.

I’m not entirely sure how these poor people catch obesity, but from the looks of things, it’s transmitted by pizza.

This PTD (

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

pizza transmitted disease) is steadily on the increase, and there are numerous fingers pointing to a lot of different causes. Lately, I’ve been thinking that there’s one that has been overlooked.

The reason that I keep seeing is similar to the reason t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

here has been an “epidemic” of dead hedgehogs since the invention of the car. It’s a simple case of cause and effect. Incidentally, this is an example of a TTD (tyre-transmitted disease) but that’s irrelevant.

The reason I keep spotting for this epidem

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

c is that either people are selectively deaf, or else people have some bizarre form of reverse anorexia where they don’t actually know they’re fat.

I’ll give you an example, just to set the ball rolling.

A while ago, I overheard a conversation between

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

a friend of mine and a woman he knew who’s husband had just lost a friend to a heart attack at the age of 47. Whilst discussing this event, dejectedly, the following sentence cropped up: “He was a heavy smoker, he drank a lot, and he liked his food… *s

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

igh* he got taken too young…”

Now, forgive me for being callous, but surely if you’re an overweight heavy smoker who drinks a lot, forty-seven is exactly the age you’d expect to live to?!

Not too long afterwards, there was an article in some rag paper

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

or another that was desperately scrounging for news it could report in words of one syllable about a man who had died on his wedding night. They really missed an opportunity by not using the headline “Man Dead in Wed Bed”, but who am I to edit?

Anyway,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the story featured, for those who couldn’t guess, a couple who had got married and then fulfilled the “til death do us part” end of things a lot faster than either party had really been banking on.

The thing that surprised me, once again, was that it

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

wasn’t in the least surprising.

The couple in question were so fleshy and round that if you squinted and held the paper at arms length they began to resemble a rather obvious boob job. In fact, by flicking from the page that contained their picture to

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

age three of the paper very fast, you could achieve an interesting doubling-up effect.

Once again, the spherical widow was presenting this as a shocking and tragic story, rather than viewing it as the rest of the world probably did, ie: “Obese Man Dies

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of Heart Attack. Nobody Surprised.”

It’s the same story everywhere you look. People peer over their bellies to see the paper and read about how fat everyone is, think it’s terrible and then go back to their fry-ups.

Now, I know that those of you who

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

regularly read my stuff - and I’d like to take this opportunity to say hello to myself when I come back to correct a typo - will doubtless be expecting me to have some sort of solution to the problem, but this is one that leaves even me stumped.

The be

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t I can come up with is that clear and present evidence does not work, so we need to be subtle. God knows I’m inexperienced with subtlety, but I have a few thoughts.

First and foremost, magazines need to stop telling us when celebrities are too thin. T

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

hey should instead have a column where they point out members of the public who are too fat.

I don’t give a toss about how thin Nicole Ritchie is. If she has to pay to go to some clinic to put weight on, which she apparently does, then that’s her probl

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

em. She might spare a thought for the millions who are dying because they can’t afford food in the first place as she forks over (no pun intended) inordinate sums of cash to be fed up, but apparently she doesn’t find this thought as obscene as I do.

So

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

like I say, if the front cover of “Heat” says “Nicole Ritchie is down to 19lbs 4 oz”, I’m unlikely to care. However, if the front cover said “Lorry Driver Barry Jones from Huddersfield: You’re Too Fat!” with a picture of said individual, I’m inclined t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

o buy the magazine out of sheer novelty value.

The second possibility is that we take a more direct route. It’s unlikely that the people in question will be reached by the pot-luck method of magazine articles. So - and I think this applies to all parts

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

of life - we need to show some solidarity and stop being afraid to hurt peoples’ feelings.

If someone who is morbidly obese comes into the pub where you’re drinking and every patron, as one, launches into a hearty rendition of “Who ate all the pie?!”

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

hen I’m sure that they couldn’t help but be moved to action.

A similar thing should be done to anyone who drinks low-alcohol beer, although I’m not sure what the song should be, yet. If we continue taking our inspiration from football terraces, however

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

, then in my area it’s likely to be “You’re Going Home in a Fucking Ambulance.”

As I say, I don’t have all the answers, I think this combination of editorial nous and public rudeness should at least set the ball and, indeed, several fat people, rolling

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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