E-Articles - Health and Fitness

Arthritis, in general terms, is wearing out of the lining of the joint, which is called cartilage. Every joint- knee or hip joint, which moves has a layer of about 8 to 12mm of cartilage, which is as smooth a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s a billiard ball. If cartilage is injured or eaten away or goes through natural wear and tear, it leads to arthritis.

Osteoarthritis is a form of arthritis which can affect any joint, including the spine. It

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

is the form of joint disease and is more pronounced in the case of elderly persons. Wear and tear of joints, due to aging leads to osteoarthritis. But this is not the single reason for the disease. There are

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

other contributing reasons such as genetic factors, lack of nutrition and vitamins, (Vitamin A, C and E have the potential to protect against tissue damage. Vitamin D plays an important role in bone mineralisa

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ion). Female hormonal deficiency in the case of post menopausal women, leading to estrogen deficiency is also considered a risk factor and women are more susceptible to osteoarthritis.

In most of the cases, i

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

creased body weight contributes to the increased load transmitted across the weight bearing knees by a factor of three to seven times the body weight and leads to accelerated damage of the cartilage.

Obesity

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

is a potential risk factor for the onset and deterioration of musculoskeletal conditions of the hip, knee, ankle, foot and shoulder. Majority of research have focused on the impact of obesity on bone and jo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nt disorders, such as the risk of fracture and osteoarthritis. However, evidence indicates that obesity may also have a profound effect on soft-tissue structures, such as tendon, fascia and cartilage. Althoug

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the mechanism remains unclear, the functional and structural limitations imposed by the additional loading of the locomotor system in obesity have been accepted to unduly raising stress within connective-tiss

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ue structures and the potential for musculoskeletal injury. Considering the global increase in obesity and the rise in musculoskeletal disorders, there is a need to determine the physical consequences of load

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ng of major structures of the locomotor system in the obese people and to establish how obesity may interact with other factors to potentially increase the risk of musculoskeletal diseases. Besides, the relati

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nship between obesity and osteoarthritis is stronger for the disease and is greater in women. The load transmitted to the knees varies with increased body weight.

Increase in life expectancy, coupled with ov

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

erweight/ obese conditions of the population shall lead to a larger number of patients with knee problems due to osteoarthritis . Several changes, metabolic as well as functional, connect obesity with Osteoart

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ritis. Random trials show substantial and clinically relevant disability and symptoms - relief in obese patients with knee osteoarthritis following moderate weight loss. While exercises are good for the functi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

nal status in general, it is advisable initially to prescribe weight loss as therapy for patients with a combination of obesity and osteoarthritis.

Treatments / Tips to avoid Osteoarthritis:

1. Avoid being o

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

bese/ overweight, with weight management diet schedule and proper exercise.

2. Ensure intake of vitamins A and C, through food and nutrient supplements.

3. Ensure muscle strength in quadriceps (thigh muscles

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

.

4. Increased activities of kneeling, squatting, climbing stairs and lifting heavy loads cause abnormal loading across the knee joint and cartilage damage. To the extent possible, this may be reduced.

5 E

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

u oil is considered to provide relief for joint pains and arthritis.

7. Liberal intake of orange juice, sweet lime juice or Vitamin C enhance the efficacy of any anti-rheumatic drug, since Vitamin C can reduc

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e skeletal pain.

8. Body massage with sesame or mustard oil helps to reduce the pain. The joints affected by pain can be massaged for longer time for pain relief.

9. Guggul, as a medicine for traditional Ayu

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

vedic treatment is prescribed for osteoarthritis and obesity. However patients electing to undergo this treatment should be closely monitored and counseled about the need for dietary modifications and exercise

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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