E-Articles - Health and Fitness

World’s most renowned health agency WHO after intense research revealed the following facts about obesity.

* More than 300 millions are suffering from obesity

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

and about 1 billion people are over weight.

* Obesity is increasing the risk of cardiovascular diseases and certain forms of cancer.

* Increase in consumpti

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

on of energy rich sugar and fat based food is making the situation worse.

Then the question arises. Why people are not trying to get rid of obesity if it is t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

at much harmful? Answer is that people are trying to reduce obesity with their 100% efforts but unable to get rid of it. Lack of knowledge about how obesity af

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

fects their bodies is a major obstacle in their way.

Medical science differentiates human body in different systems namely skeleton system, transportation sys

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

em, respiratory system, nervous system, digestive system, excretory system and reproduction system. Obesity is primarily related with digestive system and nerv

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ous system; any imbalance in these two can lead to overweight of the body. Nervous system comprises of brain and nerves, Cannabinoid-1 (CB-1) receptors are als

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

o a vital part of it. CB-1 sends the signals of hunger to brain, only after that urge for food is generated in the brain. Any substance which can benignly inhi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

it the working of CB-1 receptor can erase the problem of obesity.

Recently Sanofi-Aventis of France has launched a drug named Acomplia in the UK anti-obesity

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

drug market which can block working of CB-1 receptor efficiently. This unique job is done by its active constituent Rimonabant. Besides giving a good stature A

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

omplia can register its marks in improving cardiovascular risk factors such triglyceride, HDL, insulin tolerance and smoking cessation too. The drug not only h

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

elps in weight loss but also in maintaining the condition of weight loss. The success rate of Acomplia is quiet high in comparison to many other anti-obesity d

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

rugs.

Acomplia is an oral prescription anti-obesity drug. Drugs of this category require necessary doctor’s prescription to start their use. Generally doctors

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

prescribe 20 mg pills of Acomplia. A pill of Acomplia is daily swallowed with one glass of plain water 1 hour before breakfast. Acomplia pills should not be cr

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ushed or chewed as this can bring some unwanted changes in the matrix of the drugs.

In any case Acomplia should not be taken by the people with body mass inde

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

27 or below it. The ladies who are planning to conceive should not use Acomplia as its effects on zygote formation and on embryo are not studied thoroughly. B

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ecause of somewhat similar reasons, breast feeding mother and pregnant ladies should avoid Acomplia. Acomplia may have some initial and mild side effects like

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nausea, headache, dizziness, dry mouth and stomach disorder. All these side effects disappear with a continuous use of Acomplia for a few days.

The drug can r

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

duce about 5% of the total body weight with its use for one or two months. Acomplia is available through easy online order; many online pharmacies also arrange

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

online doctor’s prescription for the drug according to physical status of the customer. Buy online Acomplia (Rimonabant) and kick out obesity out of your life

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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