E-Articles - Health and Fitness

A large number of children and teenagers in the United States are obese, and their numbers are

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

on the rise. It is true that not all obese infants become obese children, and not all obese chi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

dren grow up to become obese adults. Still, it is more likely that obesity beginning even in ea

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

rly childhood will persist through the entire life span.

A child has to face numerous problems

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

on account of obesity. In addition to increasing the risk of obesity in adulthood, childhood ob

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

sity may cause pediatric hypertension, is linked with type 2 diabetes mellitus, increases the r

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

isk of coronary heart disease, and increases stress on the weight-bearing joints. On the psycho

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ogical side, it lowers a child’s self-esteem, and affects his/her relationships with peers. The

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e are reasons to believe that social and psychological problems are the most significant conseq

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

uences of childhood obesity.

Childhood obesity is most likely caused by an interaction of nutr

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tional, psychological, familial, and physiological factors.

The risk of obesity is greatest am

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ng children who have two obese parents caused likely by strong genetic factors.

Instead of foc

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

using on weight loss, childhood obesity treatment programs aim to slow or halt weight gain so t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e child will grow into his or her body weight over a period of months to years. Physical exerci

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e is a successful strategy for weight loss for children unless coupled with another interventio

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n, such as nutrition education or behavior modification. Without imposing too much caloric rest

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ictions, it is better to go for balanced diets with moderate caloric restriction, especially lo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

dietary fat.

As preventive measures, education for the child should include proper nutrition,

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

selection of low-fat snacks, healthy exercise habits, and monitoring of television viewing. In

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

addition, parent education may focus on building self-esteem and address psychological problems

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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