E-Articles - Health and Fitness

Since the early 1980s, the Body Mass Index (BMI) has been advocated by the World Health Organisation (WHO) and health professionals as a tool for indicat

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ing if a person is underweight, healthy, overweight obese.

Be aware that frame size, water retention, ethnicity,age, bone and muscle density can distort

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

a persons BMI. For instance a healthy bodybuilder could have a BMI above 30 (ranked obese), due to muscle mass!

Calculating your BMI
1. Measure h

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ight in metres and multiply the figure by itself.
2. Measure weight in kilograms and then divide weight by height.
Example: You are 1.65m tall

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

and weight 89kg
1. 1.65x1.65 = 2.72
2. Your BMI would be 89 divided by 2.72 = 32.72

This result shows that you fall into the very overweight c

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tegory and therefore you should consider the benefits of a Herbalife ShapeWorks Programme.
BMI Thresholds
Male
Underweight: 20

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Ideal: 20 to 25
Overweight: 25 to 30
Obese: 30 to 40
Morbid obesity: 40
Female
Unde

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

weight: 18
Ideal: 18 to 25
Overweight: 25 to 30
Obese: 30 to 40
Morbid obesity: 40

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

A recent study was made that found obesity appears to lessen life expectancy, especially among young adults. The researchers compared Body-Mass Index (B

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

I) to longevity and found a correlation between premature death and higher BMIs.

For example, a 20-year-old white male, 5 foot ten inches in height, wei

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ghing 288 pounds with a BMI greater than 40 was estimated to lose 13 years of his life as a result of obesity. While this study referenced extreme levels

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

of obesity, there are still millions of overweight people with a life expectancy rate that is three to five years less than their healthy-weight counter

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

arts.

It is therefore vital that obesity is targeted at an early age to enable people to lead a healthy and productive life. Not only will this be of ob

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

vious benefit to them, it will also relieve the pressure on the health care system, which has seen its resources stretched to the limit in dealing with t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

is growing problem.Number of obese people set to increase.Obesity is on the rise due to unhealthy lifestyles and eating habits.

By 2010 over 10 per cent

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

of the European population aged 15 and over will be obese* It is estimated that obesity will overtake smoking as the biggest cause of heart disease. Obe

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ity can also cause strokes and diabetes which puts a strain on global healthcare systems and health costs.

People are leading unhealthy lives; skipping

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

breakfast, eating junk food and lack of exercise have all contributed to the rise of obesity. The number of overweight people in the world has now topped

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

one billion.

Over the next few years, it is vital that the message gets across about health and nutrition, so that people will lead healthier lives. It

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

must be emphasised to the people the importance of healthy eating habits. *Euromonitor international,2005.

I hope this item has been of interest to you

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Many people are of the opinion that market cycles consist of only two movements, upward and downward and are thus very disappointed when a cycle refuses to respond on demand to the timing they have formulated for any given cycle. So when ones forecast falters so does their trading plan, emotions take over and losses are imminent .

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