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E-Articles - High Sugar Meals Lead to Future Disease, Not Just Obesity
A new study shows that eating meals with high sugar content causes the release of damaging substances into the blood. Parents should take special note since many kids are eating high sugar meals and snacks several times a day. This behavior is setting the stage for a lifetime of chronic disease problems.
It’s
It’s
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
all about the burn
All foods have a ‘glycemic index’, which is a measure of how fast the body burns the food to turn it into fuel. Foods with a lot of simple sugars burn very quickly while foods high in fiber and complex carbohydrates burn very slowly.
High glycemic foods that burn very quickly cause blood su
All foods have a ‘glycemic index’, which is a measure of how fast the body burns the food to turn it into fuel. Foods with a lot of simple sugars burn very quickly while foods high in fiber and complex carbohydrates burn very slowly.
High glycemic foods that burn very quickly cause blood su
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
gar to rise fast. The body reacts to this rise in blood sugar by releasing a large dose of insulin to drive the blood sugar back down. This is the reason for the ‘energy crash’ that you feel after eating a high glycemic meal.
Low glycemic foods that burn very slowly cause blood sugar to rise gently at a contro
Low glycemic foods that burn very slowly cause blood sugar to rise gently at a contro
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
lable rate. This way the body does not need to take drastic measures to keep blood sugar under control. You feel a smoother level of energy after a low glycemic meal and don’t feel the crash a couple hours after eating like you do with the high glycemic meal.
The danger of your personal reactor
The energy spi
The danger of your personal reactor
The energy spi
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ke and crash that you feel after a high glycemic meal is because the body uses blood sugar as the primary source of fuel to make an ‘energy molecule’ called ATP. However, the production of ATP is somewhat dangerous because it also leaks other molecules called ‘free radicals’, which in turn cause ‘oxidative-stre
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
s’.
Oxidative stress can be very damaging to your cells and if left unchecked this damage leads to chronic diseases like heart disease, some cancers and even depression. The damage caused accumulates in your body in places like your arteries, heart, lungs and brain and slowly leads to chronic degenerative illn
Oxidative stress can be very damaging to your cells and if left unchecked this damage leads to chronic diseases like heart disease, some cancers and even depression. The damage caused accumulates in your body in places like your arteries, heart, lungs and brain and slowly leads to chronic degenerative illn
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
ess.
Luckily, our bodies have mechanisms to keep free radical damage and oxidative stress under control. We have proteins that actually capture the free radicals and ‘neutralize’ them so that they are no longer dangerous. However, to function properly, this system requires the anti-oxidants you get from fruits
Luckily, our bodies have mechanisms to keep free radical damage and oxidative stress under control. We have proteins that actually capture the free radicals and ‘neutralize’ them so that they are no longer dangerous. However, to function properly, this system requires the anti-oxidants you get from fruits
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
and vegetables and multi-vitamin supplements.
It’s similar to the dangers involved in using nuclear energy. This is an incredibly efficient energy source as long as nothing goes wrong. If the nuclear reactor over-heats then trouble can happen. The same happens with ATP production. When blood sugar levels are h
It’s similar to the dangers involved in using nuclear energy. This is an incredibly efficient energy source as long as nothing goes wrong. If the nuclear reactor over-heats then trouble can happen. The same happens with ATP production. When blood sugar levels are h
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
igh, ATP production goes into high gear and free radical release gets out of control. High glycemic meals kick up ATP production.
It has been known for some time that eating high glycemic meals leads to oxidative stress and a new study in the July 2006 issue of The Journal of Clinical Nutrition validates that
It has been known for some time that eating high glycemic meals leads to oxidative stress and a new study in the July 2006 issue of The Journal of Clinical Nutrition validates that
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
y actually measuring signs of oxidative stress in the blood after eating both low and high glycemic meals. The study found a strong relationship between the glycemic index of the meal and the level of oxidative stress markers in the blood after the meal. High glycemic meals caused high levels of oxidative stres
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
s.
Why is this important? It means that high glycemic meals that our kids eat all the time are causing damage that will likely lead to chronic degenerative disease when they are adults. Especially when you couple this with the fact that most kids do not get the anti-oxidant protection that they need from eatin
Why is this important? It means that high glycemic meals that our kids eat all the time are causing damage that will likely lead to chronic degenerative disease when they are adults. Especially when you couple this with the fact that most kids do not get the anti-oxidant protection that they need from eatin
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
g several portions of fruits and vegetables. It’s a double whammy; increased damage and decreased protection.
Damage control
What types of foods are causing this damage? There are many common kid’s foods that are very high on the glycemic index scale. For starters, high-sugar breakfast cereals, waffles and pa
Damage control
What types of foods are causing this damage? There are many common kid’s foods that are very high on the glycemic index scale. For starters, high-sugar breakfast cereals, waffles and pa
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
cakes with lots of syrup and white toast with jam are very high glycemic foods. It’s not just sugary meals that are the problem. Foods made primarily from refined grains and white flour are just as bad. Things like white bread, macaroni and cheese, crackers and hotdog buns.
You can go a long way in protecting
You can go a long way in protecting
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
your kids current and future health by switching to whole grain cereals and breads and getting more fruits and vegetables into their diet. This is common sense stuff that people have known for a long time.
My hope in writing this article is that understanding a little more about the reason why ‘healthy foods’
My hope in writing this article is that understanding a little more about the reason why ‘healthy foods’
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
re so necessary will help motivate people to act. Just picture in your head little pick axes circulating through your kids blood every time they eat these high glycemic meals and perhaps that will help you help them make better choices.
To be realistic, food choices are all about balance. It’s not going to kil
To be realistic, food choices are all about balance. It’s not going to kil
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
l you to eat poorly every now and then. You just need to understand that it’s all about risk. The more you or your kids make poor eating choices the more damage you are allowing to accumulate and the higher your risk will be for problems later in life. Act now to instill thoughtful food choice in your kid’s beh
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
vior.
A proud moment I want to end with a brief story. Last week my 9-year old son came to work with me and we had lunch in our small cafeteria. The menu choices that day were a turkey sandwich, pepperoni pizza, soups and a salad bar. I told him he could have whatever he wanted and I was very happy when he ch
A proud moment I want to end with a brief story. Last week my 9-year old son came to work with me and we had lunch in our small cafeteria. The menu choices that day were a turkey sandwich, pepperoni pizza, soups and a salad bar. I told him he could have whatever he wanted and I was very happy when he ch
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
ose the salad bar. It’s not that he doesn’t like pizza or turkey sandwiches but he made a healthy choice on his own because he really likes salad.
A year ago, he hated everything ‘green’. My wife and I just kept putting a small amount of vegetables on his dinner plate and offering salad when we had it. We did
A year ago, he hated everything ‘green’. My wife and I just kept putting a small amount of vegetables on his dinner plate and offering salad when we had it. We did
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ot force him to eat this stuff but just kept offering it. Eventually he started to eat more and more and realized that he likes salad. Now both my kids love a wide variety of steamed vegetables and eat all kinds of fruits on a regular basis.
Kids don’t like a lot of foods when they are very young but experts h
Kids don’t like a lot of foods when they are very young but experts h
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
ave told us to just keep offering them. Eventually they will come around. Otherwise, they will grow up eating fast food for the rest of their life and be robbed of good health in there older years. Please do not rob your kids of this. Give them the greatest gift you can, their health.
Copyright 2006 Simon Evan
Copyright 2006 Simon Evan
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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