E-Articles - Health and Fitness

Journal of the American Medical Association published a research which tells that; on average Americans watch four to five hours of television per day, making it

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the most prevalent and pervasive sedentary behavior in the US. Technology has brought time and labor saving products. Cars, Elevators, dishwashers, food process

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ors, etc… have brought about a changed lifestyle where the overall energy expended is decreased. This has led to obesity. Obesity can expose you to serious healt

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

h hazards

• Heart disease and stroke is a leading cause of disability
• Diabetes - Type 2
• Cancers of the colon, rectum, prostrate in men, uterus, g

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

all bladder, cervix, ovary, breasts and colon in women
• Sleep Apnea due to interrupted breathing during sleep
• Osteoarthritis
• Gall stones and

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

gall bladder diseases.

Adults around the world are getting fatter and the obesity epidemic is becoming an alarming concern. Are you obese? Would you like to rul

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e this possibility out? A simple body mass index calculation could give you an indication. The formula for the body fat calculator is BMI = kg/m2. The weight in

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

kilograms is divided by the square of the height (in meters). If you have your height in inches, then multiply it with 0.00254. Similarly weight in pounds if mul

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

tiplied by 0.45 is converted to kilograms.

• A BMI of 19 to 24.9 is considered normal weight
• A BMI of 25 to 29.9 is considered and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

p://www.slimmingbasics.com/slimmingbasics-articles/over-weight-statistics.htm"> over weight
• A BMI of 30 and above is considered obese

Factors that i

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

nfluence obesity are many and can include genetic, environmental, and psychological as well. Excess body weight usually occurs when a person takes in more than t

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

he required amount of calories. The excess calories are converted and stored as body fat.

Research has gone into various other factors responsible for obesity.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Some say sedentary life styles and too much TV watching can influence obese behavior patterns. Other research has also included the bacteria in our intestines as

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

a causative factor as well.

What can be done to combat this epidemic?

• Research finds indicate that a significant positive effect on obese and diabetic perso

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s is the exercise patterns.
• A regular exercise can go a long way in bringing over all benefit to the body.
• It increases body metabolism.
• I

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t also strengthens the cardio vascular system.
• It strengthens the bones and muscles thereby increasing balance and coordination.
• De-stresses the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

body and increases the sense of well being.
• Helps you sleep better.

In our endeavors we should not only target increasing physical activity but also tar

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

get a decrease in sedentary behavior. Every two hours spent walking or standing at home cuts the risk of obesity around 10%. A brisk walk of an hour contributes

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

to a drop in 24% risk. Reduce your total caloric intake and more specific the dietary fat to yield better results.

Quick weight loss through weight loss surger

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

y is bad weight loss solution. Instead a healthy lifestyle of no more than 10 hours of television per week and a thirty minutes walk daily can better your health

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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There's one image of your childhood you can't erase from your mind. At the end of every weekday, your dad follows the same coming-home-from-the-office routine. He walks through the door, drops his briefcase heavily to the floor, and trudges to the living room, grunting at anyone who has the audacity to greet him. This ritual always baffled you, but over time, you realized that you must never work for someone who could turn a kind, loving person like your dad into the Grinch.

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