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  • E-Articles - Obesity - a Major Problem

    Obesity is a major problem with it affecting children as well as adults. Obesity is when there is too much stored in the body's fatty tissues. When this excess incr
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    eases, there is a corresponding increase to other medical risk as well. Some of these medical risks have the possibility to be life threatening.

    The severity of obe
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    ity is measured through body mass index (BMI). The BMI is calculated by dividing the person's weight by the square of their height. (This measurement is done in met
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    ric.) The value is separated into ranges which would represent their weight classification from underweight to severely obese.

    The cause of overweight conditions is
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    hen the energy intake from foods in greater than what the body needs. The excess is turned into fat cells and stored in the body. The amount of excess energy intake
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    is very small but over time can add up to cause the overweight condition. The factors can range from the person's diet to eating disorders to mental stress among ot
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    ers as well. There are some statistical factors showing a higher incidence of obesity with women that have married into lower economic status than women that married
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    into higher economic status.

    The best results in reducing excess weight has been in controlling diet and a moderate exercise program. Small drops in weight have cr
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    ated lower health risks for the person. Most dieters that achieve greater weight loss tend to regain the weight they lost within the next several years. Other metho
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    ds of weight loss include drug therapy and surgery. Both of these come with risk of complications and mortality risks as well.

    In many cultures, obesity represents
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    ttractiveness or wealth. This is represented in some of their art work. Someone that I talked with once commented that they were doing work overseas for their embas
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    y. They threw a party and invited several guests. One of their guests commented to them that everyone thought they were very wealthy because they put more than one
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    slice of meat on their sandwiches. Other people in foreign lands receive comments of their apparent wealth because they are over weight. When asked about the commen
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    , the reply is that people of that country could not have excessive weight unless they were wealthy because they could not buy sufficient food to be overweight.

    In t
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    he last 20 years, the obesity problems in the United States has become a very serious problem. Obesity among adults has doubled and among children has tripled. Chil
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ren under 19 years of age have an incidence of obesity of just under 20%. In adults, the rate is just over 32%. The recent increases in the obesity rates has public
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    health concerns. A quick look at the environmental issues related to this would reveal some interesting problems with activity levels in addition to marketing of fo
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    ds that lead to obesity. There are so many other factors that can effect this increase in rate. The change of job types to more desk jobs and less physically demand
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    ing jobs adds to these factors. There has been a decrease in walking since you can drive everywhere. The fast food industry has tremendously increased during this t
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    me as well.

    The bottom line is going to be people taking personal responsibility for controlling their weight problems, exercise programs and general health concerns


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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