E-Articles - Health and Fitness

My midsection is not what it use to be! The weight has creeped in with time.

Did you know that

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

if you carry excess baggage in your midsection, the risks are greater than if the extra pounds s

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ttle on your hips?

You actually place a strain on your heart and body when you're heavier than

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ou should be.

When a person without heart disease is first diagnosed with elevated blood choles

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

erol, doctors often prescribe a program of diet, exercise, and weight loss to bring levels down.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

The National Cholesterol Education Program guidelines suggest at least a six-month program of r

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

duced dietary saturated fat and cholesterol, together with physical activity and weight control,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

as the primary treatment before resorting to drug therapy.

Many people respond well to this an

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

end up sufficiently reducing blood cholesterol levels. Study data reinforce these benefits.

Fo

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

example, a 1998 Columbia University study examined 103 male and female patients of diverse ages

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

and ethnic backgrounds and found that reducing dietary saturated fat directly affected blood cho

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

esterol. For every 1 percent drop in saturated fat, the study showed a 1 percent lowering of LDL

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

in patients.

You should start by maintaining a healthy diet...set a date to start an exercise r

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

giment and stick to it.

Never go on a crash diet or fall for one of those... "lose 10lbs in 3 d

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ays".

It's not worth the risk to your health.

Set an appointment to see your medical professio

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

al to discuss your plans and get a check up.

The good news is that losing as little as 5%-10% o

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

your body weight can reduce your risk of heart disease, by lowering your cholesterol levels and

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

blood pressure and improving blood sugar and insulin sensitivity.

High cholesterol can be a pro

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

lem for anyone...large or small!

The key is cutting down on those saturated fats and replacing

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

hem with good ones.

"The decisions you fail to make today, will determine your health tomorrow"

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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