E-Articles - Health and Fitness

What is the cause of foot pain and when is it considered a problem?

Before tackling those questions, here is some foot-trivia to get a bette

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

r understanding of the subject matter - the foot. * The foot has 26 bones, 33 joints, woven in a web of 126 muscles,

nerves and ligaments

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

* In a typical day, a person spends about 4 hours on their feet and

takes between 8,000 to 10,000 steps * The foot functions both as a sho

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ck-absorber and a lever that propels

the leg forward * Each foot absorbs a force of about 150% of the person's body weight

with each step.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

With that said, is it surprising then that all of us should experience some form of foot pain at some point in our lives?

Foot pain gener

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ally occurs in one out of the three areas of the foot; the toes, the front of the foot or forefoot and the back of the foot or hindfoot. Wh

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

enever you experience any pain in your foot, make it a point to remember in which one of these three areas did the pain occur and describe

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

it to your podiatric physician accordingly.

Problems or pain in the toes is most often caused by pressure and friction imposed on the foot

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

as a result of wearing ill-fitting shoes. Pain originating in the forefoot usually involves either the metatarsal bones, which are the five

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

long bones which extend from the front of the arch to the bones of the toes and the sesamoid bones, two bones in the first metatarsal whi

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

h are connected to the big toe. Pain in the hindfoot extends from the heel across the sole (also known as the plantar, in podiatric terms)

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

to the ball of the foot.

Here are some general guidelines for the prevention of foot pain, as provided by the American Podiatric Medical

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Association: 1. Never ignore foot pain. Any persistent pain requires the attention

of a podiatric physician 2. Be sure to wash feet regula

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rly, especially between the toes and

dry them completely 3. Apart from being comfortable, shoes must fit properly. Shop for new

shoes afte

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r mid-day when feet tend to be largest 4. Do not wear the same shoes everyday by alternating your footwear 5. Avoid walking barefoot to red

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

uce the risk of injury or infection 6. Wear the proper shoe for different activities. A game of tennis and

a jog in the park would each req

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

uire different types of athletic

shoes, for example 7. Inspect feet regularly. Look for signs of peeling or scaling in the

sole, cracks an

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

d cuts in the skin or any discoloration of the nails,

for example 8. Use home-remedies for the treatment of foot pain with caution 9. A p

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

erson with a known history of heart or renal problems should

refrain from treating their own feet as they are more prone to

infections. Doi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ng so may actually make a minor problem or wound more

serious.

We will broach into the common causes of foot pain in Part 2 of this series

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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E-Articles - Foot Pain And Everything You Need To Know About Caring For Your Feet - Part 1

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