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Did you know that the knee is the most easily injured part of the human body? It is also the most complicated joint and one of the most utilized. From sitting to sta

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nding, walking to running, the knee is used—and perhaps abused. With every motion there is an increased risk of injury resulting in knee pain. And, there are many in

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

uries that can cause knee pain.

Common Causes of Knee Pain

Often, knee pain is the result of an injury, such as a ruptured ligament or torn cartilage. But some med

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ical conditions can also bring you to your knees, including arthritis, gout and infections.

Some forms of knee pain are minor annoyances, while others can greatly d

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

srupt your quality of life. Common injuries that cause knee pain include:

· Ligament Injuries. Torn ligaments are caused by a hard stop or twist of the knee that ty

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

pically occurs when participating in athletic activities. Many times, when you tear ligament you will hear a “popping” sound. This will be followed by intense knee p

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

in.

· Dislocation of the Kneecap. This is another common injury that causes a lot of knee pain. If the kneecap (patella) moves out of place, a doctor may have to sn

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ap it back in place. Ouch!

· Tendon Ruptures. Certain tendons (quadriceps and patellar) can rupture partially or completely. Many joggers experience knee pain cause

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

by tendon ruptures. Most of the time, surgery is performed on a completely ruptured tendon, while a partial rupture can heal with the aid of a splint.

· Meniscal I

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

njuries. If you hear your knee clicking or grinding while moving, or it locks in a particular position, you most like have a meniscal injury. This kind of knee pain

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

enerally happens from overuse or a traumatic injury.

Treatments for Knee Pain Injuries

If the knee pain is caused by a minor injury, try ice packs and heating pads

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

. You can also take over-the-counter painkillers, like Tylenol or Advil. However, if the pain is severe and/or lasts for a few days, do not hesitate to visit your do

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

tor. Your doctor can determine the cause of your problem. Only then can the correct treatment routine begin. Some knee injuries require surgery.

Surgeons perform mo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

re than 450,000 knee replacements in the United States each year. Two thirds of knee replacement patients are women. During the last year that statistics are availa

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

le from the Center for Disease Control, 311,000 women and 167,000 men had total knee replacements.

"There are several factors behind the increase we're seeing in kn

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ee replacement patients," says Orthopedic Surgeon Stanton Longenecker, MD. "There is an increase in the number of patients living longer and more active lives and an

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

increased acceptance of knee replacement surgery. Women are certainly more active later in their lives than they were 20 years ago. The reason for the replacements r

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

emains the same - wear and tear arthritis."

Other knee pain issues require physical therapy or stretching exercises, while other conditions may simply involve rest.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Your doctor is the only one who can make these important decisions.

For more information about knee pain, visit BigKneePain.com. This informative website will teach

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

you more about knee pain, preventative techniques, and various supplements (Glucosamine and Chondroitin) you can take to relieve some of the knee pain from injuries

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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