E-Articles - Health and Fitness

If someone has ever mentioned having a migraine and you responded with a comment about it just being a headache, then you've been fortunate enough to never have suffered from a migra

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ine - otherwise you'd never make that comment in the first place. A migraine does more than cause a bit of pain in your temples or that spot over the bridge of your nose where you ge

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

a sinus headache. This nervous system disease saps your strength, causes nausea and even makes the sufferer unable to see properly.

If you're thinking that migraines aren't very co

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

mon, these statistics may surprise you:

* In developed areas, migraines are as much as 300 to 500 percent more common than in third world and Asian countries.

* More than 500,000,0

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

0 (five hundred million) people have migraines every year.

Since millions of people worldwide suffer from migraines each year, this disease is actually fairly serious. A migraine is

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

not just a little headache - they cause people to lose work time, miss out on family events and generally enjoy life less than people who don't get them.

So what exactly are migrain

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

headaches and where do they come from?

There are actually two types of migraines. If you've been suffering from migraines and have a common migraine, it hits without warning. If yo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

have a classic migraine, you do get some warning that it is coming, but the warning isn't a nice one and is almost as bad as the headache itself. Anywhere from ten to thirty minutes

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

before the actual headache hits, people who suffer from classic migraines will have something called an aura. Auras can include many symptoms, but visual difficulties, such as flashi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

g lights, zig-zag lines and temporary loss of vision, are the most common warning signs. Other aura symptoms are difficulty with speech, feeling confused, tingling in the face or han

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

s and weakness in arms or legs.

Migraine sufferers don't always feel pain on both sides of their heads. This is because these headaches are unilateral, or on one side. Most people d

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

evelop a headache around one eye or one side of their jaw and neck. As the migraine persists, it will envelope the rest of that side of the head. During a bad migraine, noise or ligh

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

can worsen the pain and the sufferer may vomit from the pain they experience.

Another term for a migraine is vascular headache. This means that the headache happens because the blo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d vessels around and inside your skull change their shape and size. This is what actually causes the migraine pain and what makes it so difficult to treat at times.

Children rarely

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

uffer from migraines. Teen boys develop migraines earlier than girls who will eventually suffer from this disease. However, in later years, women will be more likely to develop migra

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

nes than men. The good news is that, for many people, episodes of this nervous system disease eventually becomes less intense and less frequent. The bad news is that migraines can la

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t for quite some time. There have been cases where these headaches lasted for as long as two weeks, although a range of a few hours to two days is more common. Some people have migra

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nes several times a week, while others only have two or three episodes a year.

Finally, although more than one person has feared that the terrible pain of a migraine is because of a

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

brain tumor, migraines are not caused by an underlying disease. They are very painful and dehabilitating while they are happening, but they aren't fatal at all.

There are ways to de

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

l with, cope and even treat your migraine headache and you can find more information, from a fellow, migraine sufferer by following the resource section at the bottom of this article

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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