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E-Articles - Best Migraine Prevention - Medicines or Natural Remedies
The dictionary tells us that the word "migraine" is a Middle French word, modified from the Latin word "hemicrania", meaning a pain in one half or "hemi" of the head. To the person who suffers migraine, the pain may seem bigger than that, however. In fact, the current definition of migraine includes not only recurring, excruciating
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
headache, but also nausea and possible vomiting. The dictionary fails to include the many ways in which the aura of migraine affects the body. It fails to describe the visual disturbances, the sounds and smells that are not there.
Migraine prevention is important to migraineurs because the pain and other symptoms disrupt life alm
Migraine prevention is important to migraineurs because the pain and other symptoms disrupt life alm
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
ost completely.
Migraine Prevention Medicines
We discussed in a previous article entitled "Best Migraine Prevention Medicines" the fact that many medicines, prescription and non-prescription, are claimed to have migraine prevention properties. Some seem to work for some people, while others are more likely to provide migra
Migraine Prevention Medicines
We discussed in a previous article entitled "Best Migraine Prevention Medicines" the fact that many medicines, prescription and non-prescription, are claimed to have migraine prevention properties. Some seem to work for some people, while others are more likely to provide migra
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
ine prevention for others.
There is some controversy, however, as to whether one should even try a migraine prevention medicine.
As of this article's writing (early 2007), the FDA has approved four drugs for migraine prevention: propranolol, timolol, topiramate, and divalproex sodium. Amitriptyline, an antidepressant, is also pre
There is some controversy, however, as to whether one should even try a migraine prevention medicine.
As of this article's writing (early 2007), the FDA has approved four drugs for migraine prevention: propranolol, timolol, topiramate, and divalproex sodium. Amitriptyline, an antidepressant, is also pre
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
cribed for migraine prevention. Botox has been used successfully, but is not highly recommended.
The down side of using migraine prevention medicines is the fact that all of them require the patient to take adequate doses of the medicine for a length of time to determine the effectiveness. This can cause a building adverse effect
The down side of using migraine prevention medicines is the fact that all of them require the patient to take adequate doses of the medicine for a length of time to determine the effectiveness. This can cause a building adverse effect
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
before the sufferer even knows if migraine prevention is being provided. Physicians often must experiment, finding the smallest dose that will work without unwanted side effects.
Side Effects of Migraine Prevention Medicines
Merely as an example, consider the side effects of Topamax. The makers of Topamax offer on their we
Side Effects of Migraine Prevention Medicines
Merely as an example, consider the side effects of Topamax. The makers of Topamax offer on their we
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
bsite "Important Safety Information about Topamax" under which heading they admit that serious risks are associated with the medicine. Risks such as these are given:
* Lowered bicarbonate levels in the blood: This increases blood acidity. In severe reactions, the patient might experience irregular heartbeat or changes in their abi
* Lowered bicarbonate levels in the blood: This increases blood acidity. In severe reactions, the patient might experience irregular heartbeat or changes in their abi
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
lity to remain alert. This side effect, if not treated, could eventually increase the risk of developing kidney stones or bone disease.
* Hyperventilation, i.e. deep, rapid breathing with a feeling of not being able to catch your breath.
* Fatigue.
* Increased eye pressure. Such pressure can lead to glaucoma and blindness.
The
* Hyperventilation, i.e. deep, rapid breathing with a feeling of not being able to catch your breath.
* Fatigue.
* Increased eye pressure. Such pressure can lead to glaucoma and blindness.
The
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
arnings continue, ending with "more common side effects" such as tingling in your arms and legs, losing your appetite, nausea, diarrhea, and changes in your taste that may lead to weight loss or increase.
Natural Migraine Prevention
Many believe the option of migraine prevention medicines is too risky, the side effects too
Natural Migraine Prevention
Many believe the option of migraine prevention medicines is too risky, the side effects too
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
numerous. For those individuals, there are natural migraine prevention options.
1. Migraine Triggers
One very natural method of migraine prevention is a migraine trigger diary. Make it important by purchasing a small blank book specifically for the purpose. It will cost less than a prescription, and will help you remember
1. Migraine Triggers
One very natural method of migraine prevention is a migraine trigger diary. Make it important by purchasing a small blank book specifically for the purpose. It will cost less than a prescription, and will help you remember
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
to use it. Place the book in a location where you will see it when you are not busy. Then faithfully record your daily meals, activities, weather, etc. When a migraine episode hits, look back and note what you were doing or eating just prior to its onset. Were you stressed by something? Was the weather different? As you see a patt
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
ern develop, try to eliminate those things from your life and see if it aids in migraine prevention.
2. Biofeedback
A second natural migraine prevention method is biofeedback. In biofeedback, special equipment is used to monitor physical tension in the migraineur. The goal is to teach the patient to control stress-related
2. Biofeedback
A second natural migraine prevention method is biofeedback. In biofeedback, special equipment is used to monitor physical tension in the migraineur. The goal is to teach the patient to control stress-related
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
hysical processes which may cause migraine. As the patient learns to recognize the physical tension without equipment, he can stop a rising migraine episode, or at least reduce the effects. Children seem to have a better response to biofeedback migraine prevention than do adults, probably because they are open to new methods and le
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
arn them quickly.
3. Herbal Remedies
Herbal remedies are also being used effectively for migraine prevention. Butterbur and feverfew seem particularly helpful.
Butterbur is a shrub-like plant that grows in northern Asia, Europe, and parts of North America. Butterbur extracts are used to treat migraines. Several studies in
3. Herbal Remedies
Herbal remedies are also being used effectively for migraine prevention. Butterbur and feverfew seem particularly helpful.
Butterbur is a shrub-like plant that grows in northern Asia, Europe, and parts of North America. Butterbur extracts are used to treat migraines. Several studies in
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
dicate that butterbur is good for migraine prevention. In the largest of these studies, 245 migraineurs took either butterbur extract or a placebo. After four months of treatment, butterbur was more effective than the placebo for migraine prevention. While 75 milligrams twice a day worked, 50 milligrams twice a day did not. Butterb
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
ur's side effects were mild, and included mild digestive complaints – mostly burping. Possible other side effects that were not experienced in the study include constipation, diarrhea, fatigue, headache, indigestion, nausea, and vomiting. Pregnant or nursing women, children, and people with kidney or liver disease should not take b
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
tterbur. Please ask your physician before using this herb.
Feverfew, the second herbal remedy, has been used in Europe for centuries for migraine. In England, it was especially popular in the 1980s as an alternative to conventional migraine prevention drugs. Several studies have evaluated the effectiveness of feverfew for migraine
Feverfew, the second herbal remedy, has been used in Europe for centuries for migraine. In England, it was especially popular in the 1980s as an alternative to conventional migraine prevention drugs. Several studies have evaluated the effectiveness of feverfew for migraine
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
prevention. One examined the use of a feverfew extract as opposed to a placebo in 170 migraineurs. Those who took feverfew showed a significant decrease in migraine frequency as compared to those who took the placebo. Frequency of migraines decreased by 1.9 migraines per month in the group that took feverfew. In the group taking a
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
placebo, migraine frequency decreased only by 1.3 migraines per month.
The Choice Is Yours
The choice between migraine prevention through prescription medications and migraine prevention through natural remedies is yours to make. Migraine is a very personal experience, and the migraine prevention method that works for on
The Choice Is Yours
The choice between migraine prevention through prescription medications and migraine prevention through natural remedies is yours to make. Migraine is a very personal experience, and the migraine prevention method that works for on
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
e will not necessarily work for all. Before you make the choice, get as much information as you can, and take your time.
Disclaimer: The author is not a trained professional, and provides the foregoing information for educational purposes only. It is recommended that you seek professional advice from your personal physician
Disclaimer: The author is not a trained professional, and provides the foregoing information for educational purposes only. It is recommended that you seek professional advice from your personal physician
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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