E-Articles - Health and Fitness

Neck pain is very commonly shown by most people to be in the region of the back of the neck and between t

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

he base of the neck to the shoulder, primarily indicating the region of the trapezius muscle.

Trapezius

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

is a big diamond shaped muscle with 3 parts: the upper, middle and lower portions. Trapezius forms the s

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

lope of the shoulder. It arises from the back of the skull and from the spines of the C7 to T2 vertebrae

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

. It attaches to the outer one third of the collarbone and acromion and the spine of the shoulder blade.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

It receives nerve supply from the accessory nerve and the C1 to C4 cervical nerve roots.

The trapeziu

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s functions to bring the 2 shoulder blades together toward the midline, draws the acromion backward and r

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

otates the shoulder blade upward. It functions to shrug the shoulder, pull the head and neck backward, be

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nd the neck sideways and also to turn the neck to the opposite side. Therefore with pain and spasm of th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e right trapezius, the patient will have difficulty bending the neck sideways to the right side. The pat

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ent will also have difficulty turning the face (rotation) to the opposite side.

Most patients who compla

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

in of neck pain or shoulder pain will be invariably show the pain to be at slope between the base of the

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

neck and the shoulder, in the region of upper trapezius. With pain and tightness in the trapezius, pati

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ents may have symptoms of headaches, dizziness, neck pain and midback pain.

When the latissimus dorsi (C

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

6-C8 roots) and the deltoid (C5, C6 roots) have pain or spasm and/or weakness, the trapezius will help in

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

lifting by shoulder shrug. Similarly, the trapezius will shrug the shoulder for maintaining the arm out

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

in space.

To properly release the tightness in the trapezius, the entire spine muscles from the skull t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

o the lower back, the latissimus dorsi and the gluteus muscles have to be treated. Trapezius muscle is

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

usually so tight that it is very difficult to treat and to find motor points, especially in the lower tra

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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