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E-Articles - A New Tool To Help You Recover From Pain Pill Addiction - Are You Addicted
Are you addicted to pain pills? You certainly have company. The cycle of use, dependence, and use is playing out, over and over, in every community across the country. Note that I describe the cycle as ‘use, dependence, use’—a description that is accurate, because in most cases the cycle of dependence starts when you appropriately use medication administered by a person who you trust—your physician.
Pain pills are often called ‘narcotics
Pain pills are often called ‘narcotics
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
’--a term that comes from the Greek word ‘narcosis’, or ‘sleep’—because of their sedative effects. Physicians use the word ‘narcotic’ to refer to different things in different situations. For example, when referring to controlled substances, ‘narcotics’ may be used to denote drugs regulated by the Drug Enforcement Administration. An anesthesiologist uses ‘narcotic’ to refer to the portion of the anesthetic that is comprised of drugs that
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
bind to brain ‘opiate receptors’. ‘Opiate’ is another word used by physicians in reference to pain pills. The word comes from ‘opium’, a substance derived from poppies and used to make heroin and morphine. The ‘opiate’ reference is also used for synthetic pain medications that have no connection to poppies or opium save their pain-killing effects.
Most people have heard of ‘endorphins’. Endorphins are produced in the human body, and whe
Most people have heard of ‘endorphins’. Endorphins are produced in the human body, and whe
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
released, block pain. Endorphins are often referred to as ‘endogenous opiates’ because of their role in pain sensation, even though they have no relation to poppies or opium, and are structurally quite dissimilar. These natural pain relievers have other functions in the body, roles not relevant to this discussion. Endorphins are one group out of dozens of ‘neurotransmitters’, substances involved in the communication between nerve cells.
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
Endorphins and other neurotransmitters act at ‘receptors’, the receptor being a lock on a nerve cell, and the neurotransmitter being the key that fits in the lock. Amazingly, poppies produce a substance that looks different from the natural key, but that acts like endorphins by fitting the exact same keyhole. That substance—one molecule from the sap of a red flower—has given the human species the ability to ease suffering in countless ind
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
viduals, and has resulted in the deaths of millions of others.
Over the years scientists have developed synthetic ‘opiates’ with potencies far beyond anything produced by nature. Anesthesiologists use ‘sufentanil’ reduce responses to pain during surgery. Sufentanil is extremely potent; an amount the size of one grain of salt, say one tenth of one milligram, placed on the tongue would cause respiratory arrest in a large man within seconds
Over the years scientists have developed synthetic ‘opiates’ with potencies far beyond anything produced by nature. Anesthesiologists use ‘sufentanil’ reduce responses to pain during surgery. Sufentanil is extremely potent; an amount the size of one grain of salt, say one tenth of one milligram, placed on the tongue would cause respiratory arrest in a large man within seconds
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
. More commonly opiates are taken by patients in the form of codeine, hydrocodone (Vicodin), oxycodone (Oxycontin), or hydromorphone (Dilaudid). Prescriptions for these substances are handed out to millions of people each day in response to complaints of pain.
Opiates relieve pain, and work in different areas of the brain to elevate mood, ease tension, give a subjective sensation of warmth, and cause sedation. They can cause nausea and v
Opiates relieve pain, and work in different areas of the brain to elevate mood, ease tension, give a subjective sensation of warmth, and cause sedation. They can cause nausea and v
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
miting, particularly in patients who are na?ve to them. Finally, they change the response of the brain to low oxygen and high carbon dioxide in the blood, and slow respiration. The most common cause of fatal overdose is respiratory arrest, where the brain stops sending impulses to the diaphragm, and the patient suffocates. This fatal response is most common during sleep, or when opiates are taken in combination with other sedative medicat
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
ions.
Opiates are addictive. There is no way to take them without the body adapting and becoming dependent on them. ‘Tolerance’ to pain medication begins after the first dose, when the ‘locks’ on nerve cells adjust in response to all of the ‘keys’ floating around. With time it takes more and more keys to open enough locks to cause the reaction at the nerve cell. Tolerance is one half of the process of addiction, and is the reason for ‘wi
Opiates are addictive. There is no way to take them without the body adapting and becoming dependent on them. ‘Tolerance’ to pain medication begins after the first dose, when the ‘locks’ on nerve cells adjust in response to all of the ‘keys’ floating around. With time it takes more and more keys to open enough locks to cause the reaction at the nerve cell. Tolerance is one half of the process of addiction, and is the reason for ‘wi
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
hdrawal’, the sickness that occurs when tolerance has developed and the drugs, or keys, are taken away. The other half of addiction is so-called ‘psychological’, which I suppose is accurate to a point. For some reason, once something is assigned to the psychological category, it is treated differently by physicians, patients, and the rest of society. ‘Psychological’ does not imply that a person has more control than with a ‘physical’ cond
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
ition—if anything, things occurring on a psychological level are far more difficult to recognize and treat than are physical conditions. The psychological addiction to opiates also develops very rapidly, and there is little if anything that can be done to prevent it. Psychological addiction is real, and is extremely powerful. The result is a desire to take opiates. The desire may take the form of physical symptoms, such as an increase in
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
pain, and so psychological addiction and physical addictions are intimately connected.
To health systems, time is money. Patient complaints are handled as quickly (and sometimes as superficially) as possible. When a person presents in pain, the first determination is whether the pain is a serious threat to health. The second determination is whether enough tests have been done to identify the cause of the pain. If the first answer is n
To health systems, time is money. Patient complaints are handled as quickly (and sometimes as superficially) as possible. When a person presents in pain, the first determination is whether the pain is a serious threat to health. The second determination is whether enough tests have been done to identify the cause of the pain. If the first answer is n
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
and the second answer is yes, the goal is to clear out the room for the next patient. There is a clock on the wall and a patient list in the hall, and the list has to be clear before the docs and nurses go home. And so there is the doctor—patients waiting in six rooms, more in the waiting area, and a person in the room complaining of something that isn’t going to kill him/her. And in the doc’s pocket lies a pad of paper. Amazingly, all
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
that the doctor has to do to clear the room is write on the pad and wish the patient well.
That is how addiction starts. Everyone intends well; everyone is honest; everyone is innocent. The patient is not told much about addiction. The patient isn’t told that within a few days, he will have some difficulty stopping the medicine. He isn’t told that after a week when he stops the medicine he will have some diarrhea, he won’t be able to sl
That is how addiction starts. Everyone intends well; everyone is honest; everyone is innocent. The patient is not told much about addiction. The patient isn’t told that within a few days, he will have some difficulty stopping the medicine. He isn’t told that after a week when he stops the medicine he will have some diarrhea, he won’t be able to sl
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
ep, and he will feel depressed. He isn’t told that the pain that he has might not go away, and so he may get more potent medicine, and so on, and that it will get harder and harder to stop as the medicine gets stronger. I don’t know if the lack of information really matters; most patients would likely take the pain relief medicine now, and worry about the rest later. Besides, the doctor doesn’t seem too concerned…and the patient is correc
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
t. The doctor isn’t concerned, because this was a quick case that got him nearly caught up to schedule.
Unfortunately, there are pains that do not go away, even as we patients demand relief. Doctors hate to feel impotent with patients--it is difficult to take a person’s money, and then tell him that there is nothing that can be done. And so prescriptions are written, even when the problem may be complicated, and the best advice to the pa
Unfortunately, there are pains that do not go away, even as we patients demand relief. Doctors hate to feel impotent with patients--it is difficult to take a person’s money, and then tell him that there is nothing that can be done. And so prescriptions are written, even when the problem may be complicated, and the best advice to the pa
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
ient would be ‘learn to live with it’. This phrase angers patients with pain, but sounds intelligent to patients who have struggled to get off opiates. But usually, the person with pain walks out with a prescription. As tolerance develops, the pain comes back, and the patient goes to the doctor again, this time leaving with stronger medication. Tolerance continues, meds are changed, and tolerance develops again. The doctor gets nervous ov
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
er the situation, realizing that at some point he will not have anything stronger. Suddenly calls to the doctor are not returned, or are returned by a curt nurse who sounds like the patient’s mother. The patient realizes that he is stuck, and becomes depressed. Sound familiar?
It is not your fault. I know about this stuff inside and out—I earned my PhD in Neurochemistry at the Center for Brain Research in Rochester New York, studying dr
It is not your fault. I know about this stuff inside and out—I earned my PhD in Neurochemistry at the Center for Brain Research in Rochester New York, studying dr
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
gs that cause addiction and tolerance. I administered opiate medications every day as an anesthesiologist. I literally know everything that there is to know about opiates…expect how to stop taking them. I thought I was smart enough to avoid addiction, but I was wrong—laughably wrong—and the outcome nearly killed me. It is not your fault. To get better, you will need to understand the meaning and truth of that statement. That is difficu
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
lt for some, but possible for everyone.
My next installment has better news. You can become free. You don’t need to leave your family to go to a far-away rehab center, and you don’t need to go through painful detox and withdrawal. Watch for my next installment, or visit me at my address below. There is a new development in treating people dependent on pain pills, a development that will revolutionize the way that doctors treat addiction
My next installment has better news. You can become free. You don’t need to leave your family to go to a far-away rehab center, and you don’t need to go through painful detox and withdrawal. Watch for my next installment, or visit me at my address below. There is a new development in treating people dependent on pain pills, a development that will revolutionize the way that doctors treat addiction
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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