E-Articles - Health and Fitness

It is a fact, daily stressed by doctors, dieticians and medical authorities that walking is the best form of exercise, for both

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

men and women, and across all age groups. Walking exercises virtually all parts of the body, from the feet and calves to the bac

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

k, arms, lungs and the heart. It is the most natural form of exercise, and does not carry the associated risks of jogging or str

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

enuous exercise in a gym, and is a lot less expensive.

But what if you are one of those many people who cant enjoy walking beca

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

use it causes sore feet, leg pain, back pain and uncomfortable posture. Maybe your children do not enjoy sports at school, again

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

because of foot problems and lower back problems. In these situations you need to look at orthotics.

Orthotics are orthopaedic

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

devices designed to treat or adjust various biomechanical foot disorders. They may be simple, commercially made devices, such a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s cushioned heel cups or insoles for shoes, but the best ones are insoles designed by doctors that give the user some form of pe

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rsonal adaptation of the insole.

Because perfect feet are very rare, almost anyone can benefit from orthotics. There are severa

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

l common symptoms that may indicate misalignment of the feet. You may be a candidate for orthotic devices if:

- one side of the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

sole of your shoe wears out faster than the other;

- you frequently sprain your ankle;

- you have chronic heel, knee or lower

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

back pain;

- your shins hurt;

- your toes are not straight;

- your feet point inward or excessively outward when you walk;

-

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

your feet hurt in general.

While perfect feet may be very rare, there is no such thing as an average foot. That is why Walkfit

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Insoles are much better than an over the counter insole. These insoles are designed by physicians and they come with three diff

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

erent inserts, Low, Medium and High, to insure that they are suitable for your foot. You are advised to experiment with the inse

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

rts, for about 1 hour per day, until you find the one that is best suited to your needs. They also come in a large number of dif

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ferent sizes to suit men, women and children.

When using these insoles, remember that your shoes may have extra layers already

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

in them. It is advised to remove these layers and just use the supplied insoles. Insoles are not like an instant painkiller, so

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

be patient. It could take up to three weeks to adjust to these insoles but once you do, then you will realize the huge differenc

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e they make to your walking and exercising. You will then be able to partake in the healthiest form of exercise available to you

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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