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Pain is little word for a big problem! Luckily though, there are successful pain treatments available. If you want to learn more, please read carefully. Pain can be caused by a specific i

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ncident or can simply appear from out of nowhere. It can come and go or it can stay for what seems like forever. It can range from mild to excruciating.

The real problem with pain and pain

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

anagement is deciding how to treat it. There are probably as many ways to treat pain as there are ways to create pain. But of those, there are only a handful of reliable, safe, and effective

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

treatments. The first step a physician must take in determining which treatment is best for you, is finding out how long you have had the pain, and also finding out (if possible) what caused

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

it.

Most pain can be classified into one of two categories. Pain is either Acute or Chronic.

Acute Injuries: such as a sprained ankle, strained back, or fractured hand, occur suddenly, dur

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ng activity. Acute injuries last up to 6 weeks. Signs of an acute injury include the following:

• Sudden, severe pain

• Swelling

• Inability to place weight on a l

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

wer limb

• Extreme tenderness in an upper limb

• Inability to move a joint through its full range of motion

• Extreme limb weakness

• Visible dislocation

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

or break of a bone

Chronic Injuries: usually result from overusing one area of the body while playing a sport or exercising, and last for a long period (6 weeks or longer). The following ar

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

signs of a chronic injury:

• Pain when performing an activity

• A dull ache when at rest

• Swelling

Once the source, type and duration of the pain have been dete

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

mined, the physician can then better choose a treatment plan.

There are three main pain therapies available. All effective and all safe when administered by a trained practitioner. These tr

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

atments are Acupuncture, Trigger Points and Prolotherapy. What are they? And when would a physician decide to use them?

Acupuncture- It is an ancient Chinese technique used to treat variou

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

forms of pain. It involves placing tiny needles in strategic locations on the body. There is no medicine placed in or on the needles. It is not exactly clear how acupuncture works, but i

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

does work on many people and we know that it has an effect through the autonomic and central nervous system, as well as the circulatory system. Some pains that respond well to acupuncture i

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

clude:

o facial pain

o headaches

o neuritis

o sciatica

o arthritis

o joint pain

o back pain

o shingles

o fibromyalgia

o plantar fasciitis

o costochondritis

o and other inflammato

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ry pains

Trigger Points- If your pain is acute, then it is likely still in an inflammatory stage. Some examples of this include:

o Falls

o sports injuries

o pulled, strained or knotted

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

uscles

o joint irritation

Ice or a heating pad along with Tylenol or Ibuprofen are the usual remedies, yet only provide temporary relief. A physician can inject medicine into the area to r

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

lieve the irritation and inflammation, which allows for a more rapid healing. These injections are termed Trigger Point injections and are specifically for acute pains.

Prolotherapy- This

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

reatment is for chronic ligament and tendon pain. This pain usually occurs at the joint but is often referred to other areas. Ligaments that are strained, stretched and even partially torn r

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

spond well to Prolotherapy. Areas best suited for this treatment are the larger joints such as:

o Neck

o Back

o Shoulder

o Knee

Prolotherapy is a series of injections that creates a ste

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ile inflammation in the ligaments and tendons; and through this inflammation, it causes new ligaments to grow. This process strengthens the joint, then decreases and even eliminates the pain

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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