E-Articles - Health and Fitness

Without a doubt the computer has revolutionised our lives. The trouble is that we now seem to spend hours in front of it staring at the screen – and because we are concentrating on what we are d

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

oing, we stop paying attention to the little signals our body is sending us.

Signals such as:- Aches in the neck, shoulders and back; dry eyes; difficulty in focusing on the screen properly and

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

the beginnings of a headache.

Did you realise that when you sit at your computer for too long (over 15 minutes or so) that your neck muscles start to over-tighten? This leads to a lot of neck

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

stress...and that could result in chronic headaches. These types of headache have the following signs:

• They tend to occur at the front of the head

• They are not present when you wake in the

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

morning

• They are worse toward the end of the working day

• They are not accompanied by auras

• They tend not to occur at the weekend (unless you spend a lot of your spare time in front of t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

he computer.

If you spend a lot of time in front of the computer then the muscles that control your neck start to tire. The main job of these muscles is to control the movement of the neck and

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

to keep the head in a neutral position – in other words in a position where the stresses in the joints are at a minimum. But when we are working away at the computer our heads tend to be looking

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

down a lot and this puts pressure on the joints in your neck. Then the muscles (at the back of the neck) start to overwork, eventually leading to a pulling on the back of your skull and...yes y

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

u guessed it, a headache!

Now of course it is not only sitting at the computer that can aggravate a headache. Amongst others are:

Reading with the head bent forward, sitting while slouching in

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

a chair or on a sofa, sleeping with the head or neck in odd positions and any other activity that places the head in a position that is forward in relation to the body.

Also our eyes and brain

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

react differently to the on-screen characters. Whereas our eyes can focus easily on printed material because the letters are black and have well defined edges, on the computer screen they strug

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

gle more. This is because letters on a screen have poorly defined edges and are brightest in the center whilst diminishing in intensity towards their edges. This makes it difficult for our eyes

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

o remain focused thus resulting in fatigue and burning, red eyes.

So what can you do to help yourself?

1. I suggest you start by taking regular breaks. By regular I mean every 20-30 minutes.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

2. You only have to stand up and look at something in the distance and this allows your eyes to re-focus and makes the eye muscles work.

3. While you are up, stretch out your neck, drop your sh

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

oulders back to their normal position, get a drink of water and just allow yourself 30 seconds or so away from that screen.

4. By the way, you might want to look at the position of the screen.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

It should be directly in front of you and your eyes should be level with the top edge of the monitor so that your head remains level at all times. Only your eyes should drop to look at the words

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

on the screen.

5. Also, if you are able, make sure that you are not facing the window as this tends to make you squint at the screen.

6. Poor quality screens can cause you to stare at the scre

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

en more. If you can get yourself a flat-screen monitor your eyes will thank you.

7. When we are staring at a computer screen we don't blink as often as normal. Squeeze you eyes together for a f

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ew seconds to help to relax you poor eye muscles and ensures your eyeballs stay moist and free from irritation.

8. Make sure you have adequate lighting in your study / work area and eliminate c

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

omputer screen glare.

9. You might want to think about consulting your optometrist for an an eye test.

This content is maintained by John Blachford. It may only be used with all links included

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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You wouldn't start on a trip without a map. Why start a business without a plan?

Online distribution of movies, music, software and the like could solve a few problems for both the distributers and the consumers.

There are a few things that should be done when going for an acupuncture treatment. When you make your first appointment ask if there are any things that you should know. It is always good to ask the practitioner what he recommends.

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