E-Articles - Health and Fitness

Migraines have many roles widely described as tension, stress & headache clusters. They can be brought on by poor health such as colds/flu, sinus, or poor healthcare such as nutrition, deficiency in: vitamins, iron, exercise, lack of sleep and/or oxygen deprivation, vision, dental and/or skeletal problems.

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

k of sleep is a major trigger for migraines. Be sure to get more than 6 hours sleep. As we get older, insomnia often strikes, but it’s imperative not to take naps. Naps will often cause headaches to worsen or return with a vengeance. If a nap seems absolutely necessary, ask yourself, “

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ould I be energized with only a few minutes of sleep? Is it a 10, 30 or 45 minute nap?” NEVER allow more than this at any one time. If it’s after 4PM, do yourself a favor, stay awake or you may find yourself up all night, and aching for days.

Perhaps you also have Sleep Apnea; checking into th

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

is possibility may save the nightmare of doctor bills, medication and further complications leading to seizures.

Drink PLENTY of fluids; oftentimes sudden thirst is due to lack of water the day before. Be sure to carry a bottle of water with you; and drink it! You

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

will want to stay away from colas and other drinks that are not natural. Once you start learning to drink ample water, you will realize just how nasty sodas and the like actually are—and how bad they really are for you!

Keep your sinuses clear; many a migraine has been brought on by sinus troubles

Have

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

your eyes checked; especially if you wear glasses or contacts; as well as the migraine itself, medication can often throw off your prescription; even if you've just gotten a new one! And if you work with computers, take breaks OFTEN, eye strain causes migraines.

Have your teeth checked; an infection,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

bad tooth, a sore tooth can bring on a migraine--even if you don't seem to have a toothache

Have the dentist check your jaw alignment; even a minor misalignment can cause many problems

Have your thyroid checked; Most do not understand just how much the thyroid regulate

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s the body; too much or too little thyroid will throw the body completely off balance!

Keep active! Getting good exercise and plenty of fresh air will help keep migraines away. Take a walk or bike ride, especially on breaks, instead of glued t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the TV or computer screen.

Bowel problems can also be linked to migraines. When was the last time you had a bowel movement? Be very aware of your body. Are you constipated? Do you have diarrhea? What is eaten, when it’s eaten, the time that it was eaten (was it before 7PM, how many sweets have

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

you eaten—and how often)? What type of fuel you put into the body, will yield what type of travel you get out of your body! Avoid processed cheeses, onions, chocolate, foods high in sugar, and culprit allergen foods such as almonds and mushrooms.

No food allergies? Just as we disliked foods as a child, the old

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

r we get, the more we are likely to both enjoy foods we didn’t like and become allergic to the very foods we love; so pay attention! Food allergies are very much a part and play a large role with migraines; understanding how foods affect you specifically, will help prevent a lot of pain

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

. Be careful; don’t set yourself up. Keep a record of what you have eaten—and I do mean everything that you pop into the mouth. An allergic reaction may only occur in one form but not in another (e.g. mushrooms, raw vs. jarred, canned or cooked—learn to tell the difference), and sometimes only if eaten in succ

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ssion. Over a period of 3 days you may have had it in your omelet, salad, pizza, soup and the gravy over your steak; eating it once or twice in a month may be fine, but in succession, no matter how miniscule, it might be a minefield.

Try not to allow anyone to touch your head; especially if you are tender heade

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d. Even the slightest bump can oftentimes bring on a migraine

Chiropractic care; I cannot say enough about this. If back problems are prevalent, or if you’ve had a fall or an accident of some kind, even if it’s minor, it’s well worth the trip to a reputable chiropractor (they are not all alike),

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

and may well solve all of your problems! Listen to him! An alignment can adjust your ribs which may be pressing your lungs & adjust your breathing ability, bowels, etc., etc; it’s unbelievable! There is a direct correlation to bones and how the muscles pull them, to how it affects the function/m

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

alfunction of body parts & organs, to good nutritional health and how it enhances your life. Which do you prefer, a chiro or meds or surgery? It’s a no-brainer.

Vomiting is good! It actually creates a chemical in your body which relieves the headache. When nauseous, let

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t flow! Sometimes rubbing your tummy can act as a lever for motion sickness helping to give some relief.No one can actually fully grasp the immense, intense pain of a migraine unless they have actually had one; people just know that they don’t want any part of it, but are also powerless to do anything for tho

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

se who are in such agony. Having suffered from migraines since a toddler, battled with seizures, hypothyroidism, hypoglycemia, sleep apnea and back problems, as well as cared for those with either the same, similar and/or worse problems, this author is still optimistic and most always wears a smile. Known to family and

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

friends as "The Migraine Queen", but hardly a title that one would relish, not only makes the heart go out to those who suffer the same, but allows her to help others who are still putting blankets on their windows, secluding themselves in the dark while curled up in a fetal position on the bathroom floor and/or pressi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ng their head against a wall in an effort to pinpoint the pain to stop the hurt, or help them prevent all of these altogether. It is this author's viewpoint that anyone who can help give an easy out from the world of "Migraine Hell" especially without further jeopardizing the patient's health, is qualified as an expert

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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