E-Articles - Health and Fitness

From over-the-counter and prescription drugs to mind-body techniques to acupuncture, chronic pain can be treated in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

many ways. However, no single method can guarantee you total pain relief. Rather, a combination of options may hel

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

you get rid of the pain.

Mild pain may be relieved by over-the-counter medications like acetaminophen or non-ster

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

idal anti-inflammatory drugs (NSAIDs). Although both relieve pain caused by muscle aches and stiffness, only NSAIDs

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

can reduce inflammation. Lotions or creams can also be applied to the skin in order to relieve pain from sore musc

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

es and arthritis.

If over-the-counter drugs fail to bring relief, your doctor may prescribe stronger medications l

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ke muscle relaxants, anti-anxiety drugs, antidepressants, prescription NSAIDs, or a short course of stronger painki

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

llers or steroid injections.

Patient-controlled analgesia, in which the patient is able to self-administer a pre-m

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

asured dose of pain medicine, is another method often used in hospitals. In the nerve blocking method, a drug is in

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ected around the appropriate nerve to prevent the pain message from reaching the brain. Trigger point injection is

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

method to treat painful areas of muscle that contain trigger points, or knots of muscle that form when muscles do

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

not relax.

When standard medicines and physical therapy are unsuccessful, surgical implants may be required. In in

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

rathecal drug delivery, the surgeon makes a pocket under the skin that can hold a medicine pump. A catheter, insert

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d by the surgeon, carries pain medicine from the pump to the intrathecal space around the spinal cord. In spinal co

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rd stimulation, low-level electrical signals are transmitted to the spinal cord or to specific nerves, blocking the

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

passage of pain signals. TENS (Transcutaneous Electrical Nerve Stimulation) therapy uses electrical stimulation to

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

educe pain. Psychological treatment uses safe, non-drug methods that treat your pain directly by reducing high leve

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ls of physiological stress.

In recent times, mind-body therapies, acupuncture, and some nutritional supplements ha

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e become popular. Although no concrete evidence is available, other alternative therapies such as massage, chiropra

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tic therapies, therapeutic touch, certain herbal therapies, and dietary approaches may diminish pain in some people

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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