E-Articles - Health and Fitness

When you find yourself living with pain every minute of every hour of every day, just getting up in the morning can seem like too much to ask. When you find it hard to remember the last time you weren’t in pain, it’s not unusual for fear a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nd depression to take hold and drag you into a downward spiral that makes the pain even worse. Even on good days, exercising can still be the last thing you feel like doing.

There’s evidence, however, that exercise may be one of the best

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

hings you can do to help manage chronic pain. A recent (2000) study by Martin Hoffman found that moderate exercise reduced the amount of pain people suffering from chronic back-ache perceived they felt. Other anecdotal studies and reports

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ave confirmed that sometimes, activity can work wonders.

THE RELATIONSHIP BETWEEN EXERCISE & PAIN RELIEF

Experts have suggested four possible reasons for the pain-reducing effect of activity. The first has to do with endorphins. These ar

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

chemicals your body produces naturally during exercise, which have the same kind of effect as opiates like morphine and codeine. Endorphins actually block the perception of pain, and create a general feeling of wellness, both of which are

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

invaluable to someone with chronic pain.

A second reason is that regular activity helps to improve both the ease with which we fall asleep, and the quality of our rest once we do. Pain, can become more or less difficult to deal with depen

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ing on our resource levels. Most sufferers experience difficulty sleeping when the pain is bad, which can prompt another downward spiral. Something that helps us sleep better, means more energy and resources, which in turn, allows us to cop

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e better with the pain we experience.

A third is that exercise helps release tension (see Exercise & Stress for an explanation of why). Tension, stress and frustration, as any sufferer of chronic pain will attest, increase pain levels. Thi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

means that anything that helps relax the body will also usually help reduce pain levels.

Finally, if the chronic pain occurs after an injury, targeted exercise can strengthen the muscles around the injury site, taking pressure off the inj

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

red tissue. Of course, the wrong kind of exercise can actually re-injure the area too, so it’s important to get professional guidance from a physiotherapist, or a personal trainer who specialises in rehabilitation work, rather than trying t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

go it alone.

USING EXERCISE TO HELP YOU MANAGE PAIN

An important disclaimer: this article is written assuming that, if you’re experiencing chronic pain, you’re already working with a healthcare professional to manage it (and if not, you

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

eed to be!) Check any suggestions you want to try with that professional, and follow their recommendations. Also, if an activity increases your pain levels, don’t do it. It’s OK to have muscles that are tired and slightly sore the day afte

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

. It’s not OK to experience any joint pain or sharp, stabbing pain during or after exercise, or anything that makes your chronic pain worse. If you experience any of these, seek advice from your healthcare professional as soon as possible.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

That said, the most beneficial kind of exercise depends very much on the individual. One of Optimum Life’s key principles is that activity will always do more good if it’s something you enjoy. This is even more important when you experience

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

chronic pain, when something you start dreading or tensing up about can quickly make your condition worse. Additionally, it helps if you choose activities that give you a good range of aerobic, strength, and flexibility exercises. Good po

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ential choices to start with include walking, swimming, stationary cycling, yoga or t’ai chi.

Finally, be aware that exercise will be most helpful for pain management if it’s one out of many tools you use. Medication, diet, visualisation,

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

relaxation, acupuncture and biofeedback have all been shown to have positive effects on pain individually – but the best effects seem to come from taking a multi-disciplinary approach. Take time to research the different therapies availabl

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

to you. There are a number of excellent pain management sites online – two of the more popular ones include The Chronic Pain Haven or The Mayo Clinic.

Chronic pain will never be fun to live with, but there are options available that make

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t more manageable. Give yourself the gift of being willing to try out different options until you find the combination that’s right for you, and don’t be afraid to ask for help if you need it. Meanwhile, until the next issue, may every da

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

bring you closer to your Optimum Life.

If you have any questions about this week’s article, please don’t hesitate to contact me. Otherwise, until next time, may every day bring you closer to your Optimum Life.

Copyright 2005 Tanja Gardne

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Is your company's valuable time and money being wasted by cell phones? Is there anything you can do about it? Read this article and find out.

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