E-Articles - Health and Fitness

Do you live with daily pain?

Perhaps you’ve had an injury that continually visits you with twinges of pain and just won’t go away permanently.

Do you have RSI (repetitive

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

stress injury)?

Do you have signs of RSI?

Shouldn’t you be familiar with the signs RSI in order to determine if that is what you are suffering from? These are just som

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

of the questions that accompany repetitive stress and will be asked… but what exactly is RSI?

RSI or Repetitive Stress Injury affects millions of people today. Although i

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

is commonly thought of as a work related injury, repetitive stress injury is just that… so it can and does occur from engaging in activities you love doing… if you repetit

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

vely put some sort of strain on a given part of your body.

RSI will normally affect those that are sitting at a desk (especially a computer) every day for hours on end. St

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nding in a production line hour after hour is also a very common way to develop a repetitive stress injury.

These types of continual non-varying activities can take a toll

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

on your body… and eventually your body will let you know that it is growing weary of these constant activities.

However, if aren’t aware of the warning signs or don't know

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

what to look for in the first place; how are you going to know what to do about them.

These may very well be some of the everyday aches and pains that you are suffering fr

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

m, but you don't have to live with them. You can do something about them.

So, let's take a look at the warning signs of RSI.

As with anything, your body gives you signs w

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

en something isn't quite right. The problem is that you need to be able to identify what it is that your body is trying to tell you. You need to make sure that you are in t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ne with your body and any aches, pains, or whatever it is transmitting to you. Every individual is different and everyone may or may not have the same specific warning sign

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

, but there are commonalities when it comes to RSI… and if you believe you have any it is wise to consult with your doctor.

With RSI you can have recurring pain and/or sor

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ness in your neck, upper back, shoulders, wrists, or hands. You may even experience tingling, numbness, coldness, or loss of sensations in the affected areas as well.

For

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nstance, a loss of grip, lack of muscular endurance, weakness, and fatigue are all very common signs. All warning signs of repetitive stress.

You may even have tense of ev

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

n locked muscles in your shoulders and/or arms. If you experience chronic pain or numbness as you lie in bed, this may not simply mean that your arm or hand is just asleep.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

You should take these warning signs seriously and monitor them closely. If they continue, you should not continue to go on without getting them checked out.

It is certainl

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

worth a trip to the doctor, if you begin experiencing any type of chronic pain. Listen to your body and do what is right for your body and your health. No one wants to liv

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

with pain.

Staying in good health means listening to your body and knowing of the warning signs that your body may be transmitting to you. Pay attention to the things tha

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

are going on around you or the things that are going on with your body. Only you can know for sure what is happening with your body, and if it is normal. Don’t ignore the

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

arning signs of pain… especially if the pain advances to being chronic… even if only “a little” chronic pain.

See your doctor to find out more about RSI and if you have it

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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