E-Articles - Health and Fitness

MUSCLE WEAKNESS

If a muscle is not given any work to do each little muscle fibre becomes thinner and the whole muscle begin

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s to lose its strength. Some groups of muscles become weak faster than others. When a footballer has a knee injury his quadriceps, the muscle

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

s on the front of his thigh get weak very rapidly. These muscles need exercising early on in order to increase their strength so that he can

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

eturn to his team as soon as possible. It is also very important that all patients are given exercises to restore muscle strength as soon as

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

possible and so minimise the amount of weakness that occurs. These early exercises, therefore, have to be carefully designed so as to complem

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nt the other Physio techniques. Exercises are needed for all the muscle groups in the affected area and they are adapted to suit each patient

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

's requirements.

Ideally exercises are part of the ongoing treatment once the initial pain has subsided. Muscles only respond to the demands

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

placed on them. When an injury has healed the muscles will recover in response to the amount of work they are asked to do. If the limb is fav

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

oured then the muscle will never recover its normal function. After a period in bed, during which time the leg muscles have been completely i

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

active, one feels weak at the knees when up. Stay in bed too long and the muscle fibres become so weak that one wouldn't even be able to stan

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

d up. So in the case of a long illness or a long-term injury the muscles have to be given specific work to do to build up and restore the pow

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

er required for every day living. In so many cases, due to the absence of specific exercises, a compromise is struck and the body has to make

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

do. People are heard to say - I've never had any strength in my back since my accident - my shoulder has always been weak since the car crash

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

- that's my bad leg - I'm always going over on that ankle - I've never been able to open a jar with that hand since I broke my wrist - etc.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

tc.

All of these situations are examples of inadequate muscle power. Even after a long period of time muscles can still adapt and strengthen

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

in response to stimuli from the right type of exercises. Muscular imbalance can lead to problems in the future. For instance a calf injury w

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ll result in weakness of the muscles and if not restored to normal strength running and even walking will be slightly out of kilter. This put

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s strain on other muscles and joints. By being aware of and practising 'special warm-up exercises' prior to any bout of violent exercise many

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

of the torn muscles, trapped nerves, sprained ankles or back problems which occur can be prevented. Exercises only increase the strength in m

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

uscles when they are done on a regular basis.

http://www.londonphysiocentre.com

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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E-Articles - A Solution to Muscle Weakness

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