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The start of the history of physical therapy had been acknowledged by researchers to date back as early as 3, 000 BC. The h

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

uge field of physical therapy now extends practically to all regions and in a variety of specialties, yet in those earliest

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

times, it was China that is believed to have the best masseuses, and they also practiced on joint manipulation, soon later

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

–acupuncture.

Then again, the rich history of physical therapy could not be attributed to China alone. In Greece, Hippocr

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ates was able to make out the practice of hydrotherapy and massage as early as 460 BC. And in England, the British Medical

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Journal had called for the foundation of a physical therapy institute to regulate the practice of masseuses formally under

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

the hands of qualified midwives and nurses within the 1890’s.

Nonetheless, the evolution of the history of physical therap

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

y may be indebted to its nature itself and its practiced philosophy. The early history of physical therapy pioneered a view

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

that the body’s health and fitness be treated according to the workings of biomechanics and kinesiology. There could be no

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

other way to explain the success of the practice throughout the entire history of physical therapy other than its scholarl

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

expertise on the mechanics of the human body. As testimony to this proficiency, we can look at the rigorous test and train

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ing that the physical therapy discipline went through the two world wars.

The two world wars awoke the need for PT. We can

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

declare that the history of physical therapy has finally stitched its mark permanently during its superlative stature in W

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

orld War I and II. It was during these times that the vital role of physical therapy became ever more pronounced to the wor

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ld. The use of physical therapy shed light to the dark events of blood spills and had left much knowledge for use of future

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

practitioners. In irony, the painful rehabilitation of injured soldiers paved way to the rise of a highly specialized PT,

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

as spinal injury units, orthopaedic hospitals, chest clinics, and other facilities provided new challenge and promise to th

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e profession.

And well up to these moments, physical therapy has been progressing as one of the largest allied professions

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

in health care – research, development, technology, expertise, expansion. Whether it began through a simple prick on the s

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

kin or massive catastrophic deaths, the history of physical therapy owes much to the moment when humans learned how to care

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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