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Doesn’t water suggest life? Since the dawn of time, water has possessed an overflow of revitalizing healing properties. Water cleanses, purifi

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

es, soothes. In more medical terms it eliminates inflammation and infection. Helping healing better, and more cheaply, than many of our chemic

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

lly advanced concoctions, the simple molecule does so much more it may be futile to ask why – just how.

In hydrotherapy or aquatic physical t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

erapy, patients are gently immersed in warm water. This form of underwater therapy aims to assist patients to overcome conditions where moveme

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t is limited because of paralysis or pain, or where the patient’s muscles have been weakened due to injury or illness. Water immersion allows

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

atients to exercise painlessly, even pleasurably, aiding a hasty recovery from a wide variety of conditions.

Aquatic physical therapy has bee

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

n used for decades as an integral part of treatment for severe arthritis or post knee or hip surgery. Fibromyalgia or rheumatic syndrome, a co

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

dition characterized by body aches, pain, sleep disturbances, fatigue, and anxiety, combined with tenderness and whose cause is unknown, is al

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

o healed by aquatic physical therapy. Ankylosing Spondylitis, a form of arthritis where the spinal vertebrae become progressively inflamed and

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

the spine eventually becomes fused, making movement very limited, also benefits from the hydro treatment. Even in some serious neurological co

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ditions, the aquatic physical therapy can increase mobility as well as the power in the muscles by allowing movement in muscles normally unabl

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e to move. Though it cannot help the illness, aquatic physical therapy can also help to re-instruct muscles to get over damage from stroke or

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ccidents.

Regrettably, aquatic therapy still has its share of limitations. Pure water therapy cannot help patients who are incontinent for hy

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

iene reasons, as well as those with skin conditions or allergies to chlorine. And it is unsuitable for people who have high blood pressure as

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ydrotherapy raises the blood pressure.

Nonetheless, hydro/aquatic physical therapy especially helps therapists help their patients because be

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ng immersed in warm water makes the buoyant movement much easier as the water lifts the limbs, improving joint movement and getting the joints

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

working effectively again, in contrast to painful movement against gravity.

The qualified aqua therapist has three primary objectives in per

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

orming therapy in warm water for his patients: to abolish gravity, allowing the body to float and amplifying the power in the muscles, and pro

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

iding greater movement of a specific limb or joint; to conduct gentle exercises because of its effective resistance to movement; and to relax

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

he muscles and ease the pain with the water’s warmth and healing powers. And to look at it simply, hydrotherapy is just an underwater exercise

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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