E-Articles - Health and Fitness

You long for firmer muscles and smaller waist. Everybody does. Do you think you can’t lose weight? Yes, you can. But the truth is you can’t lose weight wit

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

hout a diet – a plan.

Low Carb Diet

Weight-loss experts and diet plan authors all agree that much of our excess weight comes from the carbohydrates we ea

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t, especially the highly refined or processed ones such as potatoes, baked goods, bread, pasta and other convenient foods. To aggravate the problem, few of

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

us get enough exercise to ward off excess pounds.

The basic science behind the low carb diet is to limit the consumption of foods with a lot of carbohydra

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

tes. The low carb diet includes many popular weight-loss programs such as the Atkins, South Beach, Zone and Carbohydrate Addict Diet.

Does It Really Work?

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

One of the food groups which the body needs to survive are carbohydrates. Carbohydrates also referred to as carbs come in two types – sugars and starches.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Sugars are simple carbs usually sweet tasting like biscuits and sweets and easily digested. Whereas, starches are complex carbs found in bread, pasta, noo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

les and rice and take longer to digest.

The body transforms all these digestible carbs into glucose, the sugar that our cells use as fuel or energy. When

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

glucose molecules pass from the intestine into the bloodstream, the pancreas releases insulin, a hormone that mobilises cells to absorb it. Muscle, fat and

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

other cells then absorb the excess glucose from the blood and insulin levels return to normal.

After a meal high in glycemic index (ranking of foods accor

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ding to how fast their sugars are released into the bloodstream), blood-sugar levels rise higher and rapidly. The insulin needed to fill all that sugar int

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

o muscles and fat cells also weaken the activity of glucagon, a hormone that signals the body to burn stored fuel when blood-sugar levels fall below a cert

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

in point. Glucose level drops so low leaving the body starved for energy. The brain and intestine then send out hunger signals. New cravings are created re

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

quiring more carb intake. We, then overeat that leads to more fat, rise in blood insulin level, more hunger, and more weight gain and the cycle goes on.

O

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the contrary, adhering to a low carb diet puts an end to this cycle. Reduced carbohydrates would mean decreased insulin level, increased glucagon level, w

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

eight loss, improved triglycerides (fats carried in the blood which are necessary but when excessive cause coronary damage), decrease in LDL (bad cholester

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

l), increase in HDL (good cholesterol).

The bottom line – Give refined or processed carbohydrates which cause rapid changes in blood sugar, trigger hunger

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

, thereby encouraging overeating that ultimately leads to obesity smaller spots on your plate. Anyway, nobody ever died from skipping potatoes, pasta, rice

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

and white bread.

That said; go get yourself a few good low carb cookbooks. Better still, leaf through this site’s 1,000+ low carb recipes – a seemingly en

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

dless variety of recipes. Try every recipe imaginable and make this diet as enjoyable and diverse as possible.

Yes, you can diet. Lose weight! Live longer

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.e-article.org.ua/article/262883/e-article-The-Science-of-Lowcarb-Diets-Why-They-Work.html">The Science of Lowcarb Diets: Why They Work</a>

BB link (for phorums):
[url=http://www.e-article.org.ua/article/262883/e-article-The-Science-of-Lowcarb-Diets-Why-They-Work.html]The Science of Lowcarb Diets: Why They Work[/url]

Real estate speculators have a golden opportunity, in foreclosure properties, to save money. Because both the homeowners of houses in foreclosure and the lenders holding the mortgages on them are only hoping to make back what they have loaned on the home or pay what they owe, it may be available for well below market value.

A look at how there is a connection between the Aura and the Human Body and Consciousness.

Meals are being eaten on the run. Fast food is commonplace and 'going out to play' has been replaced with video games and movie rentals. Is it any wonder we are in this situation? Most adults would rather not deal with it, it is easier to pretend everything is all right and just put some chicken nuggets in the microwave and call it dinner.

Tags

Links

E-Articles - The Science of Lowcarb Diets: Why They Work

Related Articles: