E-Articles - Health and Fitness

Though easy to grab the habit, giving up smoking is no easy task. Amongst all addiction, nicotine addiction is the hardest to quit, infact it is harder to quit than c

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ocaine and alcohol. Most people inspite of having the knowledge that smoking is harmful for health still continue to smoke; it is because they are addicted to nicotin

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e.

Nicotine’s addictiveness is linked to its capacity to trigger the release of dopamine in the brain which is further associated with feelings of pleasure. Research

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

, however has found that in the long run, nicotine which is an alkaloid, depresses the ability of the brain to experience pleasure. Therefore, smokers gradually incre

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

se their intake of nicotine to achieve the same level of satisfaction.

Every year nearly 35 million people want to quit smoking of which only 6 percent actually manag

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e to quit. Nicotine withdrawal symptoms include irritability, craving, cognitive and inattentive, sleep disturbances and increased appetite. These symptoms may begin w

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ithin a few hours after the last cigarette and subside within a few weeks, however, for some, symptoms may last for months. The first few days of smoking cessation are

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the hardest; they change normal life into a chaos.

A new research has revealed that a few minutes of physical activity like walking can help reduce cigarette craving

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

and withdrawal symptoms. The findings of the research “The acute effects of exercise on cigarette cravings, withdrawal symptoms, affect and smoking behaviour: a syste

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

matic review” was published in the journal, Addiction (Vol. 102, No. 4: 534-543) in its April 2007 issue.

The research conducted by the University of Exeter, United K

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ingdom after examining 14 studies of the effect of exercise on cigarette cravings, withdrawal symptoms, mood, or smoking behavior among smokers who were trying to quit

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

, either permanently or temporarily, found out that cigarette cravings significantly reduced when a person is involved in physical exercises like brisk walking and eve

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

low-intensity activity like isometrics.

“If it takes an average of 6 minutes to smoke a cigarette, then doing a brisk walk for this period may be sufficient to help

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

remove the urge” says Adrian Taylor, who leads the research is an associate professor in exercise and health psychology at Exeter. He also says “People tend to think o

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

f exercise as a visit to the gym, or requiring the need to put on specific clothing, or to be done on a set number of days a week, or only possible on weekends when ti

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

me is less of a problem.” Therefore, if you are not taking any medical aid, next time when ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

"_blank">withdrawal symptoms hit you; take a long walk to curb the urge. Besides it makes you healthier as well.

However, there are medical aids availabl

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e now to combat the withdrawal syndromes. Pfizer’s chantix is one of them. You can easily buy c

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

hantix from one of the authentic drug stores and induce smoking cessation. The drug was approved by FDA for the treatment of anti-smoking in adults. With

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

Varenicline as its main component, chantix has the ability to diminish the taste of cigarette and fight the craving. Thus, it helps the smokers to quit smoking for lif

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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An increasing number of studies have shown the effectiveness of proper enzyme intake to combat heart disease, help diabetics control their blood sugar levels and help alleviate arthritic symptoms. All important to your health and aging process.

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