E-Articles - Health and Fitness

Did you know that you are risking yourself to erectile dysfunction by smoking cigarette? Before you shrug off the statement, let me tell you that Action on Smoking and Health (ASH) an

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

d the British Medical Association (BMA) estimate that up to 120,000 UK men in their 30s and 40s are impotent as a direct consequence of smoking. Now, still I can see the signs of doub

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t on your face. You need concrete reasons to quit smoking, am I right? I understand that you are pretty addicted to the four-inch-fire-stick and need to breathe in till the end of it.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

But if you lose your sexual pleasure for good in lieu to the pleasure of smoking, will you not be a loser in this bargain?

Sexual functioning requires balanced coordination among ho

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

rmones, nervous system to carry stimulation and healthy vascular system to pump blood to the penile tissues to cause a proper erection. Absence of any component among them will inevi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tably lead to erectile dysfunction. Now, what is the contribution of smoking in causing erectile dysfunction? Smoking affects the vascular system by narrowing down the blood vessels t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

hat contributes to the blockage of arteries; therefore the penis gets insufficient blood pumped into it, which results in a failed erection. Strokes and heart attacks are other life t

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hreatening diseases which can be caused by smoking. Now, let me tell you that smoking increases the risk of erectile dysfunction by 50% for men in their 30s and 40s. Let us see what n

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

icotine actually does to the male private part to negate an erection.

 Atherosclerosis, a fatty deposit in the arteries, built up by long term smoking, blocks the inflow rout

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e of blood into the penis.
 Acute Vasospasm, a result of nicotine stimulation sent to the brain, causes rapid contraction in the penile tissues. This situation restricts

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

blood flow into the penis.
 The presence of nicotine in the blood stream damages the valve mechanism that traps blood in the penis. This problem is known as venous dila

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tion.
 Nicotine also reduces the volume of ejaculation.
 It lowers sperm count and the sperm develops an abnormal shape.
 The sperm motility is

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

also impaired by nicotine.

Cigarette smoke contains about 4000 chemicals, most of which are supposed to damage the vascular system. The most dangerous chemicals are carbon monoxide,

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nicotine, and butadiene, causing thousands of deaths and millions of heart attacks, arthritis and impotence. A sheer fact can be deduced from the following findings; cigarette smokin

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

g results systemic arterial damage. We can infer another fact that impotence or erectile dysfunction is a signal to other life threatening diseases like heart attack, stroke and other

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

heart and artery related problems.

The awareness related to the adversities of cigarette smoking is very low when it comes to erectile dysfunction. The smokers who are reading this

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

article, I request them to analyze and weigh up their situation. If you have experienced the above mentioned symptoms related to your sexual life, you are in a deep soup. But at the s

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ame time, let me tell you, the situation is not irreversible. You can go back to your healthy sexual self just by quitting cigarette smoke. If the level of addiction is too high, ther

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e are therapies and medicinal help available for quitting cigarette, seek help from your doctor. Quit smoking right now so that you do not have to spend money on Viagra in future. Rat

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

her leave this smoking habit altogether, you will save your health, your sexuality and your money for a better life ahead.

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tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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E-Articles - Statutory Warning: Smoking is Injurious to Sexual Health

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