E-Articles - Health and Fitness

Once you realize you have spots,which by itself can cause you great emotional distress, there is a choice of acne treatments from which to chose. Please note, an insta

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nt complete cure, is unlikely. These various methods have the aim of preventing new spots forming, to improve those present and reduce or even prevent scarring.

1 Hom

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Treatment.

Keep the affected area clean,but do not over wash, as this could dry out the surface. Some natural oil needs to remain so the skin can maintain its na

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tural condition. Over-the-counter remedies. A number of the are available from pharmacies to treat a mild condition. Antibacterial agents such as benzoyl peroxide is

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ormally the active component. Commercial Examples: Clearasil Max or Oxy.

The active antibacterial properties in benzoyl peroxide, encourage the skin to dry out. The s

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

urface layer becomes flakey and is shed. The overall effect of combining the antibacterial and dry out process, makes it harder for the the tiny pores or holes, to bec

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

me blocked.

Benzoyl peroxide does have a downside. It may cause a reddening of the area or peeling,usually at the start of application. Moderate use can reduce some o

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

f the effects so they are less notable.

It can take a long time for these home applications to work,weeks or even months before a noticeable positive result is seen.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

lease see your doctor if after 2 months self application has not worked or you have severe acne.

2 Prescription medicines

Your Doctor may start by prescribing a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

benzoyl peroxide preparation. If this is unsuccessful,or a more sever type, there are other options available. One type, you rub onto the surface. Another is the table

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

form. So lets see what these typical applications are.

3 Topical or rub on.

Here some of the more common prescribed applications. Skinoren or azelaic acid, is

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ne alternative to benzoyl peroxide. This may be kinder to your skin as well. Rub on retinoids are based on vitamin A, such as Adapalene. This encourages the outer sur

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

face layer to flake off.

Also a rub on antibiotic lotion. When used,the lotion has a controlling effect on P.acnes bacteria. Example Dalacin T. Around six months is n

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rmally given for a course of medication.

Other preparations that use both antibiotic and other medication are also available. Benzamycin uses an antibiotic and benzoy

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

l peroxide.

4 Oral or tablet.

A number of tablet alternatives you may be prescribed are as follows.

Antibiotics in tablet form,like tetracycline, are normally p

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

escribed against an inflammatory condition. Usually taken for a period of three months or so, yet benefits may take any where from four to six months to be seen. Commo

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

n antibiotics can interferer and cause a resistance to build up in the bacteria, so effecting a successful outcome.

Contraceptive tablets can help women who have acne

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

A mix of ethinylestradiol, the normal pill hormone and cyproterone acetate, suppresses male hormone activity and is often used with women who have breakout's of spots

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

.

An oral retinoid can be used. An example here is Roaccutane,an isotretinoin,which can be used in tablet form. Isotretinoin dry's up the oily secretions and is norma

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ly used with people who have an acute or severe forms. Side effects are known to exist with particular acne treatments, so use should only be under medical supervision

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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