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Eczema & atopic dermatitis are skin conditions that are characterised by chronic itching, dryness, redness and superficial inflammation of th

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e skin. Constant scratching can also cause the skin to split, leaving it prone to infection. In infected eczema the skin may crack and weep (

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

wet’ eczema).

The site of the eczema lesions the skin is often irritated and inflamed. Topical use of corticosteroids can damaged the underl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ying structure of the skin by stopping or reducing collagen production (collagen forms the underlying matrix or structure of the skin) In eff

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ct this means that skin healing is even more difficult. Topical creams that lessen inflammation and promote healing will reduce reliance on c

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

rticosteroids but in the long term also strengthen the skin. The other key factor is to keep the skin hydrated. Dry skin exacerbates eczema.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Emollients create a physical barrier on the skin helping to retain moisture. Emollients containing olive oil are useful in psoriasis, eczema

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

and dermatitis treatment; they slow the loss of water through the skin layers and are also nourishing, helping to reduce inflammation and imp

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rove the texture of the skin.

Maintaining adequate moisture can relieve the pain of dry skin and reduce scaling and inflammation, without ca

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

sing any side effects. Regularly applying thick lotions and creams directly to the skin is sometimes very effective in clearing the symptoms.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

A good rule of thumb is to use lotions on wet spots of eczema, and thicker creams and ointments on dry patches of skin.

Topical application

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

of creams or salves that contain one or more of the following herbs may help relieve itching and redness as well as promote healing:

• Calen

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ula officinalis – is anti-inflammatory and healing so ideal for skin repair.
• Chamomile (Matricaria recutita) – is anti allergenic, an

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ti inflammatory, and pain relieving. It is ideal for skin that is sensitive, red or dry and recommended for flaky, dry & itchy skin condition

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

.
• Manuka Honey - Active Manuka Honey is a great treatment for reducing the infection, inflammation and itching. There is scientific e

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

idence that this form of treatment is effective in eliminating inflammation, itching and bacteria causing infection.
• Pumpkin seed ext

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ract – this is a rich source of zinc which is essential to skin healing.
• Birch Oil – analgesic and antiseptic which is especially goo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

where there is pain and inflammation.
• Sausage Tree extract (Kigelia) - antibacterial, anti-fungal and anti-inflammatory
• Sesame

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Oil – anti-inflammatory

As well as topical agents, less frequent bathing and showering reduce the risk of the skin drying out (dry skin is

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ore prone to eczema). Lukewarm water is best. Be wary of deodorant soaps, bubble baths, and perfumed products, all of which can worsen eczema

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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