E-Articles - Health and Fitness

If your skin is congested or you have clogged pores and blackheads there are a number of steps you can take to reduce these effects. Fir

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

stly, it is good to understand why your skin becomes congested. Each 3 or 4 weeks the skin replenishes the skin cells. This natural proc

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ss creates a layer of dead skin cells over the surface of the skin. If not removed, the dead skin cells create dull looking skin. The ot

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

her thing that may happen is that the dead cells will plug the pores on your face and create congestion and blackheads. When combined wi

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

h excessive sebum production, this can lead to the formation of white-heads and pimples.

The key to stopping congestion and clogged por

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s is to ensure the top layer skin remains clear by regularly removing the dead skin cells. There are a number of very effective products

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

you can use to remove dead skin cells.

Regular use of facial exfoliants or scrubs will help clear dead skin cells that block pores. Ex

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

oliation is necessary at least once a week (twice depending on the degree of congestion). Removing the top layer of dead cells will also

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

allow your moisturiser or serum work more effectively as it comes into contact with live skin cells rather than dead ones.

There are a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

couple of things to look for in a good exfoliant. The most obvious, although it is surprising how many people ignore this, is that a bod

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

scrub is too harsh to be used as a facial scrub. Look for a very fine, soft exfoliant as your facial skin is soft and delicate. A harsh

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

scrub may actually scour the surface of your skin much like a scrubbing brush and this can actually damage skin cells. Gentle exfoliants

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

that will slough off cells without a harsh scrubbing effect.

Fruit enzymes are another way of clearing dead skin cells. They work as a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

result of their ability to break the bonds between dead skin cells that form at the surface of the skin. Skin normally has a dead layer

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

f cells at its surface (the corneocyte layer), and fruit enzymes can speed up the normal process of skin cell regeneration and sloughing

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

. This results in increased flexibility of the skin as well as decreased formation of large dry skin flakes at the surface of the skin.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Pumpkin, pineapple and pawpaw provide natural, gentle enzyme proteases that loosen the glue between dead skin cells, slough away impurit

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

es, dead skin cells and unplug the pores while delivering nutrition to the skin. This leaves the skin cleansed and silky smooth and redu

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ces the likelihood of blackheads. Fruit enzyme ‘peels’ only need to be used once or twice a week for good effect.

Removing dead skin ce

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ls is a key step in clear, vibrant skin. Done regularly you will notice a difference in the texture and level of congestion in your skin

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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