E-Articles - Health and Fitness

Herbs have been used in maintaining and enhancing the condition of the skin since time immemorial. More recently the use of essential oils and nutrients has been incorporated into our skin care rituals. Herbs, nutr

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ients and essential oils offer a range of actions that directly impact the epidermal and dermal layers of the skin promoting a reduction in damage to skin cells as well as promoting the overall health of the skin b

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

y maintaining good moisture levels and sebum balance. Actions of these herbs and nutrients are many and varied including antioxidant, anti-inflammatory, astringent, moisturising and anti-microbial as well as anti-a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

geing effects. Some key skin care ingredients have more than one beneficial action.

With any skin care products, there are base ingredients that provide essential nutrition and a moisturising effect where as activ

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e ingredients are more likely to have a therapeutic effect on the skin.

One of the key base ingredients used in skin care formulations is Aloe barbadensis gel. Aloe has a powerful soothing, calming effect on skin

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

and so is good on mild burns and sunburn. It is also an excellent moisturiser with good penetration qualities ensuring it carries synergistic nutrients through to the deeper layers.

Avocado oil is another penetrat

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ing base ingredient that can rapidly transport active substances into the skin. Rich in lecithin, plant sterols and fat soluble vitamins, it has a protective effect on the skin as well as being an excellent carrier

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

. Avocado oil is ideal for drier skin that is finely textured.

Jojoba oil is a unique base ingredient as it is very fine liquid wax that is completely stable to oxidation. It penetrates into the dermis layer, enha

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ncing skin hydration and softness as well as helping reduce fine lines. Jojoba oil is ideal for all skin types however it is light enough to be used for oily skin as well.

Active ingredients are needed in smaller

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

quantities than base ingredients and are considered to have a more targeted and therapeutic effects. Alpha lipoic acid is a nutrient that is used extensively as an internal antioxidant. Increasingly it is also bein

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

g used in skin care as a topical antioxidant. The unique benefit of Alpha lipoic acid is that it works to dampen free radical damage in both the watery and oily part of our cells. It also works to regenerate other

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

important skin antioxidants, such as Vitamins C and E.

Vitamin B5 is another ingredient used both internally as well as topically to great effect. It acts to hold water in the epidermal layer of the skin as well a

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s promoting skin healing.

Another herb you may recognise is Ginkgo biloba. Due to its very high level of bioflavanoids, Ginkgo can help reduce free radical damage, one of the promoters of skin ageing. Internally G

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

inkgo works to improve circulation. Externally the herb also has this effect, working to improve the microcirculation under the eyes and thereby reducing the appearance of dark circles.

Tea is becoming an increasi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ngly popular ingredient in skin care as well. In particular Green Tea Leaf extract which is derived from the unopened bugs of the camellia sinensis plant. White Tea is a powerful antioxidant which reduces sun damag

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e as well as boosting cellular immune function.

One novel ingredient that stems from a natural source is Squalene from olive oil. Squalene works on the epidermal layer of the skin to help protect against moisture

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

loss as well as having a deeper effect on the dermis by improving skin elasticity. As a carrier it also effectively delivers active ingredients into the skin.

Essential oils are also prevalent in many modern skin

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

and hair care ranges. Among the most popular are Chamomile, a very effective anti-inflammatory ingredient ideal for red or sensitive skin, Geranium an astringent ideal for combination and oily skin types and Jasmin

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e which is used for dry and aggravated skin and scalp.

Herbs, nutrients and essential oils now have an established place in skin care as is evidenced by the variety of product ranges now routinely including one or

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

a number of these natural ingredients. The benefits to the skin are considerable and these ingredients can certainly enhance the effect of the products you use and of course enhance the look and feel of your skin.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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